Study of new routes for purification of fission 99Mo
DOI:
https://doi.org/10.15392/bjrs.v9i2.1623Keywords:
99Mo fission, 99Mo purification, 99Mo sublimationAbstract
99mTc is the most applied medical radioisotope in the world, especially for cancer diagnosis procedures. It is provided by 99Mo radioactive decay, which is one of the fission products from the uranium irradiation in nuclear reactors. At the main production plants, the 99Mo chemical processing may be lined up in several steps to separate it from other fission products according to the features of the used targets or the local requirements as well. In this work, two routes of 99Mo purification, MR1, and MR2, were purposed as an alternative to be set up in the Brazilian Multipurpose Reactor project (BMR). The MR1 route was performed by three chromatographic columns packed with Dowex 1x8 resin, Chelex resin, and alumina, respectively. The route MR2 was carried out also by chromatography applying two columns filled with Dowex 1x8 and alumina respectively, but including a sublimation process performed in a tubular oven under programmed conditions. The final yield for the MR1 route was 84.4 % and the overall time process was about 7 hours, whereas the MR2 route reached 75.3 % in 9 hours.
Downloads
References
SAHA, G. B. Fundamentals of nuclear pharmacy, 5 Ed. New York, N.Y.: Springer, 2003.
AHMAD, M.; VANDEGRIFT, G.; CRISTINI, P. Molybdenum-99 (99Mo): Past, Present and Future”. Science and Technology of Nuclear Installations, v. 2014, p. 1-3, 2014.
National Academies of Science, Engineering, and Medicine (USA). Opportunities and Ap-proaches for Supplying Molybdenum-99 and Associated Medical Isotopes to Global Markets: Proceedings of a Symposium. Washington, DC: The National Academies (2018).
SHITAKA, I.; IGUCHI, A. Production of 99Mo and its applications in nuclear medicine. Jour-nal of Radioanalytical and Nuclear Chemistry, v. 102, p. 533-550, 1986.
TAUHATA, L.; SALATI, I.; DIPRIZIO, R.; DIPRIZIO, M. A. R. R. Radioproteção e Dosi-metria: Fundamentos, 5 rev. Rio de Janeiro: IRD/CNEN, 2003.
AQUINO, R. A.; VIEIRA, F. M. M. Molibdênio-99, Crise e Oportunidade, Scientific Ameri-can, v. 98, p. 82, 2010.
PERROTA, J. A.; A. J. SOARES. RMB: The New Brazilian Multipurpose Research Reactor. Atomwirtschaft, v. 60 (1), p. 30-34, 2015.
VANDERWALT, T. N.; COETZEE, P. P. The isolation of 99Mo from fission material for use in the 99Mo/99mTc generator for medical use. Radiochimica Acta, v. 92, p. 251–257, 2004.
MUENZE, R.; BEYER, G. J.; ROSS, R.; WAGENER, G. NOVOTNY, D.; FRANKE, E. JE-HANGIR, M. PERVEZ, S.; MUSHTAQ, A. The fission-based 99Mo production process ROMOL-99 and its application to PINSTECH Islamabad. Science and Technology of Nuclear Installations, v. 2013, p. 1-9, 2013.
LEE, S. K.; BEYER, G.; LEE, J. S. Development of industrial-scale fission 99Mo production process using low enriched uranium target. Nuclear Engineering and Technology, v. 48, p. 613-623, 2016.
LAVINAS, T. Purificação do molibdênio-99, obtido a partir da fissão do urânio-235, utili-zando-se a resina Chelex-100. Msc Science IPEN-USP, São Paulo, 1998.
SAMEH, A.; ACHE, H. J. Production techniques for fission molybdenum-99. Radiochimica Acta, v. 41, p. 65-72, 1987.
BOYD, R. E. Technetium-99m generators: the available options. The International Journal of Applied Radiation and Isotopes, v. 33, p. 801-809, 1982.
ANKITA, R.; ABHISHEK, K. S.; PRADEEP, K.; CHARYULU, M. M.; TOMAR, B. S.; RAMAKUMAR, K. L. Studies on separation and purification of fission 99Mo from Neutron Activated Uranium Aluminum Alloy. Applied Radiation and Isotopes, v. 89, p.186-191, 2014.
Published
Issue
Section
License
Copyright (c) 2021 Brazilian Journal of Radiation Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing: The BJRS articles are licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
How to Cite
