Perfomance analysis of a small animal PET scanner using 68Ga Isotope
DOI:
https://doi.org/10.15392/2319-0612.2025.2844Keywords:
PET, galium-68, Image QualityAbstract
In recent years, the use of PET scanners for small animals in preclinical research has been growing in Brazil, due to this fact it is essential to have a quality assurance program to ensure the good performance of these scanners or indicate the need for corrective maintenance. In 2008, the National Association of Electrical Equipment Manufacturers (NEMA) in the USA published a document that proposes the following tests to ensure quality control: uniformity, spill-over ratio, and recovery coefficients. Thus, the objective of this work was to evaluate the image quality of the PET scanner for small animals LabPET SOLO 4 using the isotope Gallium-68. The results revealed that the use of the isotope 68Ga was quite different from standard tests using 18F. The project provided us with a comprehensive understanding of the functioning of the PET scanner when employing the radionuclide 68Ga. This evaluation is of crucial relevance for application in laboratories, especially in the quantitative analysis of PET images and in the planning of preclinical studies
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[1] Silva, A.V.; Gontijo, R.M.G.; Ferreira, A.V. “Quality control in small animal pet scanners: analysis of the brazilian scenario in 2024.” in: Semana Nacional de Engenharia Nuclear e da Energia e Ciências das Radiações. Anais. Belo Horizonte (MG) UFMG, 2024. Available at: https//www.even3.com.br/anais/vii-sencir-semana-nacional-de-engenharia-nuclear-e-da-energia-e-ciencias-das-radiacoes-449507/913858-quality-control-in-small-animal-pet-scanners--analysis-of-the-brazilian-scenario-in-2024. Accessed on: 01/23/2025.
[2] Kleynhans J.; Ebenhan T.; Sathekge M. M.; Expanding Role for Gallium-68 PET Imaging in Oncology; Seminars in Nuclear Medicine ; V. 54, Issue 6, November 2024, P. 778-791 (2024).
[3] NEMA - National Electrical Manufacturers Association. Performance Measurements of Small Animal Positron Emission Tomographs; Rosslyn VA, Standards Publication NU 4-2008 (2008).
[4] Gontijo, R.M.G., “Image quality evaluation of a small animal PET scanner,” Brazilian Journal of Radiation Sciences, vol. 08-01, pp. 1–13 (2020).
[5] IGT Generator, “Instructions for Ge-68/Ga-68 Generator Operation”, Manufacturer's Manual Technical. Second Version (2015).
[6] CAPINTEC CRC 25® Owner´s Manual, Capintec. Inc, 7 Vreeland Road, 2017-05-09.
[7] Gontijo, R.M.G.; Ferreira, A.V.; SILVA, J.B.; LEWER, M. H. M. Estudo dos parâmetros de reconstrução em imagens MicroPET. In: XII Congresso SBBN, 2017, São Paulo. XII Congresso SBBN, (2017).
[8] Gontijo, R.M.G., “Image quality evaluation of a small animal PET scanner,” Brazilian Journal of Radiation Sciences, vol. 08-01, pp. 1–13 (2020).
[9] GE Healthcare Technologies, “Triumph Service Guide”, Technical Publication, 2011.
[10] AMIDE: Amide's a Medical Imaging Data Examiner, validate: CSS & HTML. Project hosted by: Source Forge. Last modified: 2012-10-17.
[11] BELCARI, N. et al. NEMA NU-4 Performance Evaluation of the IRIS PET/CT Preclincial Scanner. IEEE Transactions on Nuclear Science, 2017. v.1, n.4, p. 301-309.
[12] National Institute of Standards and Technology, Available in: https://www.nist.gov/pmL/radiation-dosimetry-data. (2025).
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Copyright (c) 2025 Victória Garcia Moreira, Anna Clara Moreira Silva, Rodrigo Modesto Gadelha Gontijo, Andréa Vidal Ferreira

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