Uso da Solução Fricke Modificada com Corantes para um Controle em Tratamentos Fototerapêuticos
DOI:
https://doi.org/10.15392/bjrs.v3i1A.143Palabras clave:
Solução Fricke, Tumor, Tratamentos Fototerapêuticos,Resumen
Due to the fact that, absorb light efficiently, dyes and pigments (photosensitized) are characterized by their ability to absorb visible light, and to participate in photochemical reactions. These dyes are used in medicine in the recommended dose for use in photodynamic therapy (PDT). There are lasers that can work with most of the phototherapeutic agents and are capable of providing light of considerable power with precision on the injured tissue. The use of light emitting diodes (LEDs) have become feasible, reducing the cost of the procedures. The Chemistry Dosimetry Laboratory CRCN / CNEN has worked with some dye use in phototherapy treatments, including: methylene blue, malachite green and toluidine blue. Samples are prepared with a volume of 2.6 mL of the Fricke solution modified by the addition of dyes and ethanol, that was transferred into test tubes and they were irradiated with light: red, blue and green LED array (12-19). This procedure was realized by 24, 48, 72 and 96 h, using test tubes located in the acrylic surface simulator 110 mm x 110 mm x 80 mm perpendicular to the central axis of the radiation beam at a distance of 6.5 cm from the light source. Obtaining excellent correlations (above 0.97) showing proportionality between irradiation time and optical density measured. Suggests that the dosimeter can be applied to perform a quality control in photodynamic therapy. However, others experiments, should be performed before a wide application of this technique.
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ALMEIDA, M. G. O., LIMA, V. L., NASCIMENTO, R. K., Souza, V. L. B. 2013. Comparação entre o comportamento dos dosímetros FAM e FAT após irradiação com LED. Sci. Plena, 9(8), 081004-1 – 081004-9.
AUSTERLITZ C., SOUZA V. L. B, CAMPOS D. M. T., KURACHC. I, BAGNATO V., SI-BATA C. Enhanced Response of the Fricke Solution Doped with Hematoporphyrin under X-Rays Irradiation. Braz. Arch. Biol. Technol., v. 51, n. 02, p. 271-279. 2008.
BENSTEAD K., MOORE J. V., The effect of combined modality treatment with ionising radia-tion and TPPS-mediated photodynamic therapy on murine tail skin, Br. J. Cancer, v. 62, n. 1, p. 48-53. 1990.
COLASANTI A., KISSLINGER A., QUARTO M., RICCIO P., Combined effects of radiotherapy and photodynamic therapy on an in vitro human prostate model, Acta Biochim. Pol., v. 51, n. 4, 1039–1046 2004.
DOUGHERTY, T. J.; GOMER, C. J.; B. W HENDERSON.; JORI G., KESSEL D., KORBELIK M., MOAN J., PENG Q. Photodynamic Therapy, J. Natl. Cancer Inst., v. 90, n. 12, p. 889-905. 1998.
LUKŠIENĖ Z., Experimental evidence on possibility to radiosensitize aggressive tumors by por-phyrins, Medicina Kaunas, v. 40, n. 9, pp.868-874 2004.
MÜLLER S., WALT H., DOBLER-GIRDZIUNAITE D., FIEDLER D., HALLER U. Enhanced photodynamic effects using fractionated laser light. J. Photochem. Photobiol. B: Biol., v. 42, n. 1, pp. 67 – 70. 1998.
NÚÑEZ S. C., Efeito da dinâmica de fotodegradação e agregação das fenotiazinas azul de meti-leno e azul de orto-toluidina com relação à eficiência fotodinâmica. Tese (doutorado), Instituto de Pesquisas Energéticas e Nucleares, São Paulo. 2007.
PODGORSAK M. B. Fricke radiation dosimetry using nuclear magnetic resonance. Tese de Doutorado em Física, no departamento de McGill da Universidade de Montreal. (1989).
SCHAFFER,M. SCHAFFER P. M. et al., Photofrin as a specific radiosensitizing agent for tu-mors: studies in comparison to other porphyrins, in an experimental in vivo model, J. Photochem. Photobiol., v. 66, n. 3, p. 157-164. 2002.
SCHAFFER M., SCHAFFER P. M. et al. Application of Photofrin II as a specific radiosensitis-ing agent in patients with bladder cancer--a report of two cases, Photochem. Photobiol. Sci. v. 1, n. 9, pp. 686-689. 2002.
SCHAFFER M., ERTL-WAGNER B., et al., Porphyrins as radiosensitizing agents for solid neo-plasms, Curr. Pharm. Des., v. 9, n. 25, p. 2024-2035. 2003.
SCHAFFER M., ERTL-WAGNER B., et al., The Application of Photofrin II® as a Sensitizing Agent for Ionizing Radiation-A New Approach in Tumor Therapy?. Curr. Med. Chem., v. 12, n.10, p. 1209-1215 2005.
SIBATA C. H., COLUSSI V. C. et al., Photodynamic therapy: a new concept in medical treat-ment, Braz. J. Med. Biol. Res. v. 33, n. 8, p. 869-80. 2000.
SOUZA V. L. B., CUNHA M. S., SANTOS C. D. A., FIGUEIRÊDO M. D. C., RODRIGUES K. R.G., LIRA G. B. S., D. B., MELO R. T. A radiossensibilidade da solução Fricke dopada com corantes utilizados para fins terapêuticos. Rev. Bras. Pesq. Desenv., v.13, p.122–125. 2011.
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