Computational simulation of low energy x-ray source for photodynamic therapy: a preliminary study
DOI:
https://doi.org/10.15392/bjrs.v9i1.1639Palabras clave:
photodynamic therapy, radiotherapy, Monte Carlo, TOPAS, x-raysResumen
Photodynamic therapy is a therapeutic modality capable of selectively inducing cytotoxic effects in malignant cells. Such effects are obtained by using a laser or a lamp as a light source to irradiate a previously-delivered photosensitizer into the tumoral cells. Since clinical application of photodynamic therapy depends on light penetration, lasers and lamps can only be used for shallow tissue treatment. To overcome this limitation, x-ray induced photodynamic therapy has been recently proposed. The goal of this work is to investigate the x-ray interactions in a medium containing a homogeneous concentration of distinct photosensitizers. This is achieved by evaluating the relative doses and energy spectra, obtained at distinct depths by means of Monte Carlo simulations. Preliminary results for the relative dose showed a minor dose increase, of approximately 0.15%, when photosensitizers are used. In addition, x-ray interactions with the investigated photosensitizers mostly occur from photons with energies below 60 keV.Descargas
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AGOSTINIS, P. et al. Photodynamic therapy of cancer: an update. CA: a cancer journal for clinicians, v. 61, n. 4, p. 250-281, 2011.
LARUE, L. et al. Using X-rays in photodynamic therapy: an overview. Photochemical & Photobiological Sciences, v. 17, n. 11, p. 1612-1650, 2018.
BRAATHEN, L. R. et al. Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. Journal of the American Academy of Dermatology, v. 56, n. 1, p. 125-143, 2007.
KURWA, H. A.; BARLOW, R. J. The role of photodynamic therapy in dermatology. Clinical and experimental dermatology, v. 24, n. 3, p. 143, 1999.
FOOTE, Christopher S. Mechanisms of photosensitized oxidation. Science, v. 162, n. 3857, p. 963-970, 1968.
KALKA, K.; MERK, H.; MUKHTAR, H. Photodynamic therapy in dermatology. Journal of the American Academy of Dermatology, v. 42, n. 3, p. 389-413, 2000.
HENDERSON, B. W.; BUSCH, T. M.; SNYDER, J. W. Fluence rate as a modulator of PDT mechanisms. Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery, v. 38, n. 5, p. 489-493, 2006.
ZHU, T. C.; FINLAY, J. C. The role of photodynamic therapy (PDT) physics. Medical physics, v. 35, n. 7Part1, p. 3127-3136, 2008.
BRANCALEON, L.; MOSELEY, H. Laser and non-laser light sources for photodynamic therapy. Lasers in medical science, v. 17, n. 3, p. 173-186, 2002.
CAPELLA, M. A. M.; MENEZES, S. Synergism between electrolysis and methylene blue photodynamic action in Escherichia coli. International journal of radiation biology, v. 62, n. 3, p. 321-326, 1992.
MATSUBARA, T. et al. Methylene blue in place of acridine orange as a photosensitizer in photodynamic therapy of osteosarcoma. In Vivo, v. 22, n. 3, p. 297-303, 2008.
KUSUZAKI, K. et al. Acridine orange could be an innovative anticancer agent under photon energy. In Vivo, v. 21, n. 2, p. 205-214, 2007.
HASHIGUCHI, S. et al. Acridine orange excited by low-dose radiation has a strong cytocidal effect on mouse osteosarcoma. Oncology, v. 62, n. 1, p. 85-93, 2002.
KUSUZAKI, K. et al. Translational research of photodynamic therapy with acridine orange which targets cancer acidity. Current pharmaceutical design, v. 18, n. 10, p. 1414-1420, 2012.
KUSUZAKI, K. et al. Clinical outcome of a novel photodynamic therapy technique using acridine orange for synovial sarcomas. Photochemistry and Photobiology, v. 81, n. 3, p. 705-710, 2005.
KUSUZAKI, K. et al. Clinical trial of photodynamic therapy using acridine orange with/without low dose radiation as new limb salvage modality in musculoskeletal sarcomas. Anticancer research, v. 25, n. 2B, p. 1225-1235, 2005.
NAKAMURA, T. et al. A new limb salvage surgery in cases of high‐grade soft tissue sarcoma using photodynamic surgery, followed by photo‐and radiodynamic therapy with acridine orange. Journal of surgical oncology, v. 97, n. 6, p. 523-528, 2008.
MATSUBARA, T. et al. A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas. Oncology reports, v. 21, n. 1, p. 89-94, 2009.
MATSUBARA, T. et al. Clinical outcomes of minimally invasive surgery using acridine orange for musculoskeletal sarcomas around the forearm, compared with conventional limb salvage surgery after wide resection. Journal of surgical oncology, v. 102, n. 3, p. 271-275, 2010.
KUSUZAKI, K. et al. Clinical trial of radiotherapy after intravenous injection of acridine orange for patients with cancer. Anticancer Research, v. 38, n. 1, p. 481-489, 2018.
PERL, J. et al. TOPAS: an innovative proton Monte Carlo platform for research and clinical applications. Medical physics, v. 39, n. 11, p. 6818-6837, 2012.
POLUDNIOWSKI G. et al. SpekCalc: a program to calculate photon spectra from tungsten anode x-ray tubes. Physics in Medicine & Biology, v.54, n.19, p. N433–N438, 2009.
SPIGA, J. et al. Experimental benchmarking of Monte Carlo simulations for radiotherapy dosimetry using monochromatic X-ray beams in the presence of metal-based compounds. Physica Medica, v. 66, p. 45-54, 2019.
ALVA-SÁNCHEZ, M.; PIANOSCHI, T. Study of the distribution of doses in tumors with hypoxia through the PENELOPE code. Radiation Physics and Chemistry, v. 167, p. 108428, 2020.
TAKAHASHI, J.; MISAWA, M.; IWAHASHI, H. Combined treatment with X-ray irradiation and 5-aminolevulinic acid elicits better transcriptomic response of cell cycle-related factors than X-ray irradiation alone. International Journal of Radiation Biology, v. 92, n. 12, p. 774-789, 2016.
KIM, S. et al. PubChem 2019 update: improved access to chemical data. Nucleic acids research, v. 47, n. D1, p. D1102-D1109, 2019.
ACREE J. R.; W. E.; CHICKOS, J. S. Phase Transition Enthalpy Measurements of Organic and Organometallic Compounds, NIST Chemistry WebBook, NIST Standard Reference Database Number 69, PJ Linstrom and WG Mallard, Eds. National Institute of Standards and Technology, Gaithersburg, MD. Retrieved September, 2016.
KUSUZAKI, K. et al. Total tumor cell elimination with minimum damage to normal tissues in musculoskeletal sarcomas following photodynamic therapy with acridine orange. Oncology, v. 59, n. 2, p. 174-180, 2000.
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Derechos de autor 2021 Brazilian Journal of Radiation Sciences (BJRS)
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