The image reconstruction influence in relative measurement in SPECT / PET / CT animal

Autores/as

  • Sarah Soriano , Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission
  • Thiago Barboza Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro
  • Sérgio Augusto Lopes Souza Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro
  • Lidia Vasconcellos de Sá Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission

DOI:

https://doi.org/10.15392/bjrs.v6i1.305

Palabras clave:

SPECT/PET/CT animal, reconstruction, preclinical study

Resumen

The objective of this study was to evaluate spatial resolution and the influence of different reconstruction methods in a FLEX Triumph ™ Pre-Clinical Imaging System images applied to mice C57BL6 dosimetry in a new radiopharmaceuticals development for humans use. CT and SPECT images were obtained from a homemade phantom containing four spheres with diameters (d) simulating iodine-accumulating injuries at University Hospital (HU / UFRJ). The SPECT images were reconstructed with filtered back projection method (FBP) and the influence in resolution and partial volume effect was evaluated for different filters: Hamming, Hann and Ramp. The resolution found was 9.3 to 9.4 mm, significantly lower than the value provided by the manufacturer, 1.6 mm. Thus, the protocol for mice can be optimized by FBP reconstruction method and Hamming filter, 0.5 cut-off, yielding a resolution from 9.3 to 9.4 mm. This value indicates that iodine-accumulating regions diameter below 9.3 mm is not quantifiable.

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Biografía del autor/a

  • Sarah Soriano, , Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission
    Pos Graduation student, Medical Physics Department
  • Thiago Barboza, Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro
    Pos Graduation student, Radiology Department
  • Sérgio Augusto Lopes Souza, Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro
    Radiology Department
  • Lidia Vasconcellos de Sá, Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission
    Medical Physics Department

Referencias

MARTIC- KEHL, I. MSCHIBLI, R., SCHUBIGER, A. P. Can animal data predict human outocme? Problems and pitfalls of translational animal research. Eur J Med Mol Imaging,v. 39, p. 1492-1496, 2012.

MEIKLE R S, KENCH P, KASSIOU M, BANATI BR. Small animal SPECT and its place in the matrix of molecular imaging technologies. Phys Med Biol, v. 50, p. R45-R61, 2005.

POWSNER R. A, POWSNER E. R. Essential Nuclear Medicine Physics, Blackwell Publisher, Boston & United States of American, 2006.

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Publicado

2018-01-28

Número

Vol. 6 Núm. 1 (2018)

Sección

Articles

Licencia

Licencia: los artículos de BJRS tienen una licencia internacional Creative Commons Attribution 4.0, que permite el uso, el intercambio, la adaptación, la distribución y la reproducción en cualquier medio o formato, siempre que se otorgue el crédito correspondiente al autor o autores originales y a la fuente, proporcione un enlace a la licencia Creative Commons e indique si se realizaron cambios. Las imágenes u otros materiales de terceros en el artículo están incluidos en la licencia Creative Commons del artículo, a menos que se indique lo contrario en una línea de crédito al material. Si el material no está incluido en la licencia Creative Commons del artículo y su uso previsto no está permitido por la regulación legal o excede el uso permitido, el autor deberá obtener el permiso directamente del titular de los derechos de autor. Para ver una copia de esta licencia, visite http://creativecommons.org/licenses/by/4.0/

Cómo citar

The image reconstruction influence in relative measurement in SPECT / PET / CT animal. Brazilian Journal of Radiation Sciences (BJRS), Rio de Janeiro, Brazil, v. 6, n. 1, 2018. DOI: 10.15392/bjrs.v6i1.305. Disponível em: https://bjrs.org.br/revista/index.php/REVISTA/article/view/305. Acesso em: 17 jul. 2025.