Constancy tests and quality assurance of the activimeters used in a Radiopharmaceutical Production Unit

Autores/as

  • Rodrigo Modesto Gadelha Gontijo Universidade Federal de Minas Gerais image/svg+xml
  • Andréa Vidal Ferreira Center of Nuclear Technology Development (CDTN/CNEN);
  • Leonardo Tafas Constantino Nascimento Center of Nuclear Technology Development (CDTN/CNEN);
  • Flávia Mesquita Costa Center of Nuclear Technology Development (CDTN/CNEN);
  • Juliana Batista Silva Center of Nuclear Technology Development (CDTN/CNEN);
  • Marcelo Mamede Center of Nuclear Technology Development (CDTN/CNEN); Federal University of Minas Gerais (UFMG)

DOI:

https://doi.org/10.15392/bjrs.v7i2A.588

Palabras clave:

Quality Control, Nuclear Medicine, Dose Calibrator.

Resumen

Activimeters (or dose calibrators) are essential instruments to verify activity of radiopharmaceutical after production and also before the dose administration in humans or animals for molecular imaging. The efficiency and safety measurements depend on, beside other factors, constancy tests and quality assurance. Thereby, the aim of this work was to perform constancy tests and quality assurance in the activimeters of the UPPR/CDTN, based on the CNEN-NN 3.05 Brazilian standard and the manufacturer's manual. Physical inspection, auto zero, background check, camera voltage, data check and constancy test were done. In addition, accuracy and precision tests were performed using a set of standard certified radioactive sources (57Co, 133Ba and 137Cs), according to the CNEN NN 3.05 Brazilian standard. Linearity test was also performed to evaluate the response of the equipment in over the entire range of activities used in routine. The equipments are periodically submitted to the quality control tests and the results were compared. After performing the proposed tests it is possible to conclude that activimeters are in accordance with the requirements of the CNEN standard and manufacturer´s manual. A quality control checklist was prepared to guide users and to record the results of quality assurance testing to monitor the equipment performance. This initiative is part of the quality assurance program implemented at UPPR.

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Biografía del autor/a

  • Rodrigo Modesto Gadelha Gontijo, Universidade Federal de Minas Gerais

    Radiopharmaceuticals Research and Production Unit, Center of Nuclear Technology Development (CDTN/CNEN);

     Department of Anatomy and Imaging, Federal University of Minas Gerais (IMA/UFMG)

  • Andréa Vidal Ferreira, Center of Nuclear Technology Development (CDTN/CNEN);

    Radiopharmaceuticals Research and Production Unit, Center of Nuclear Technology Development (CDTN/CNEN);

  • Leonardo Tafas Constantino Nascimento, Center of Nuclear Technology Development (CDTN/CNEN);

    Radiopharmaceuticals Research and Production Unit, Center of Nuclear Technology Development (CDTN/CNEN).

  • Flávia Mesquita Costa, Center of Nuclear Technology Development (CDTN/CNEN);

    Radiopharmaceuticals Research and Production Unit, Center of Nuclear Technology Development (CDTN/CNEN).

  • Juliana Batista Silva, Center of Nuclear Technology Development (CDTN/CNEN);

    Radiopharmaceuticals Research and Production Unit, Center of Nuclear Technology Development (CDTN/CNEN).

  • Marcelo Mamede, Center of Nuclear Technology Development (CDTN/CNEN); Federal University of Minas Gerais (UFMG)

    Radiopharmaceuticals Research and Production Unit, Center of Nuclear Technology Development (CDTN/CNEN);

     Department of Anatomy and Imaging, Federal University of Minas Gerais (IMA/UFMG)

Referencias

AAPM - American Association of Physicists in Medicine. The Selection, Use, Calibration, and Quality Assurance of Radionuclide calibrators used in Nuclear Medicine, Report of AAPM Task Group 181. June (2012).

IAEA – International Atomic Energy Agency. Quality Assurance for Radioactivity Meas-urements in Nuclear Medicine. Technical Report Series Nº 454, Vienna, (2007).

IAEA – International Atomic Energy Agency. Quality Control of Nuclear Medicine Instru-ments. IAEA-TEC-DOC-602, Vienna, (2007).

CNEN - Comissão Nacional de Energia Nuclear. Requisitos de segurança e proteção radioló-gica para serviços de medicina nuclear, Norma CNEN NN 3.05. December (2013).

CAPINTEC, Inc. Owner´s Manual. Copyright 2006. Revision H. http://www.capintec.com/support/manuals. March (2015).

International Atomic Energy Agency. Live Chart of Nuclides. https://www-nds.iaea.org. July (2017).

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Publicado

2019-02-07

Número

Vol. 7 Núm. 2A (Suppl.) (2019): ENAN 2017

Sección

The Meeting on Nuclear Applications (ENAN)

Licencia

Derechos de autor 2021 Brazilian Journal of Radiation Sciences (BJRS)

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

Licencia: los artículos de BJRS tienen una licencia internacional Creative Commons Attribution 4.0, que permite el uso, el intercambio, la adaptación, la distribución y la reproducción en cualquier medio o formato, siempre que se otorgue el crédito correspondiente al autor o autores originales y a la fuente, proporcione un enlace a la licencia Creative Commons e indique si se realizaron cambios. Las imágenes u otros materiales de terceros en el artículo están incluidos en la licencia Creative Commons del artículo, a menos que se indique lo contrario en una línea de crédito al material. Si el material no está incluido en la licencia Creative Commons del artículo y su uso previsto no está permitido por la regulación legal o excede el uso permitido, el autor deberá obtener el permiso directamente del titular de los derechos de autor. Para ver una copia de esta licencia, visite http://creativecommons.org/licenses/by/4.0/

Cómo citar

Constancy tests and quality assurance of the activimeters used in a Radiopharmaceutical Production Unit. Brazilian Journal of Radiation Sciences (BJRS), Rio de Janeiro, Brazil, v. 7, n. 2A (Suppl.), 2019. DOI: 10.15392/bjrs.v7i2A.588. Disponível em: https://bjrs.org.br/revista/index.php/REVISTA/article/view/588. Acesso em: 17 jul. 2025.