The effect of gamma radiation on the structure of graphene oxide and graphene oxide functionalized with amino-PEG

Jaqueline Jamara SOUZA SOARES

doi:10.15392/bjrs.v7i2A.635

Autores/as

Jaqueline Jamara SOUZA SOARES

DOI:

https://doi.org/10.15392/bjrs.v7i2A.635

Palabras clave:

Functionalization, nanocomposite, graphene oxide.

Resumen

The functionalization of graphene oxide (GO) with polyethylene glycol (PEG) has been widely used in drug delivery systems. This nanocomposite exhibits excellent stability in the presence of high concentrations of salts and proteins and shows to be less toxic than its raw form in vitro and in vivo. However, it must be sterilized before use in the medical field and the gamma irradiation shows a promising option for this purpose. Sterilization by ionizing energy through gamma rays, generated by Cobalt-60 self-disintegration, consists in exposing the materials to short electromagnetic waves. The irradiation process provides substantial advantages when compared to thermal and chemical processes such as more precise control of the process, production of products with superior qualities, lower energy consumption and less environmental pollution. In this work the effect of gamma radiation on the structure of GO and GO functionalized com Amino-PEG (GO-PEG-NH2) irradiated with different doses (15, 25, 35 and 50 kGy) and rate dose 7.31 kGy.h - 1 was evaluated. The analyses were performed by Fourier-transform infrared spectroscopy (FT-IR) and Raman spectroscopy. The results showed that the methods for the synthesis of GO and GO-PEG-NH2 was effective since there was confirmation of the surface oxidation of materials and functionalization with the PEG-NH2 and the sterilization by gamma radiation does not caused any defects on materials.

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Referencias

MEHL H.; MATOS F. C.; NEIVA E. G.; DOMINGUES S. H.; ZARBIN A. J. G. Efeito da variação de parâmetros reacionais na preparação de grafeno via oxidação e redução do grafite, Química Nova, v. 37, n°10, pp. 1639-1645, (2014).

GULZAR A.; YANG P.; HEI F.; XU J.; YANG D.; XU L.; JAN M. O. Bioapplications of graphene construted functional nanomaterials”, Chemico-Biological Interactions, v. 262, pp. 69-89, (2017).

NISHIDA E.; TAKITA H.; KANAYAMA I.; TSUJI M.; AKASAKA T.; SUGAYA T.; SAKAGAMI R.; KAWANAMI M. Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering, Japanese Journal of Applied Physics, v. 53, 13, May. (2014).

ZHANG Y.; NAYAK T. R.; HONG H.; CAI W. Graphene: a versatile nanoplatform for biomedical applications, Nanoscale, v.4, pp.3833-3842, (2012).

KRISHNA K. V.; MÉNARD M.; VERMA S.; BIANCO A. Graphene-based nanomaterials for nanobiotechnology and biomedical applications, Nanomedicine, v. 8, pp.1669–1688, (2013).

XU Z.;WANG S.; LI Y.; WANG M.; HUANG P. Shi. Covalent functionalization of graphene oxide with biocompatible poly (ethylene glycol) for delivery of paclitaxel, Applied materials e interfaces, v.6, pp.17268-17276, (2014).

FENG L.; LIU Z.; Graphene in biomedicine: opportunities and challenges. Nanomedicine, v.6, pp. 317-324, (2011).

CLELAND M. L.; Industrial Applications of Electron Accelerators, Ion beam applications IBA Tecnhnology Group 151, New York. (2005).

HUMMERS W. S.; OFFEMAN R. E.; Preparation of graphitic oxide. J. Am. Chem. Soc., v.80, pp.1339–1339, (1958).

MUTTER M.; Soluble polymers in organic synthesis: I. Preparation of polymer reagents using polyethylene glycol with terminal amino groups as polymeric component, Tetrahedron Letters, Germany, n.31, pp.2839-2842 (1978).

YANG K.; FENG L.; HONG H.; CAI W.; LIU Z.; Preparation and functionalization of graphene nanocomposites for biomedical applications, Nature Protocols, v. 8, n. 12, (2013).

COLLINS C. J. Reactions of primary aliphatic amines with Nitrous acid, Advan. Chem. Phys, v. 4, (1970).

AWASTHI G.; KUMAR A.; SANGUI A.; SINGH S. S. Biochemical Laboratory Manual, International E-Publication, pp. 30-31, (2013).

ZHAO J.; LIU L.; LI F.; Graphene Oxide: Physiscs and Applications, London: Springer, 161 p. (2015).

GEORGAKILAS V. Functionalization of graphene, Wiley-VCH, p. 426, (2014).

KING A. A. K.; DAVIES B. R.; NOORBEHESHT N.; NEWMAN P.; CHURCH T. L.; HARRIS A. T.; RAZAL J. M.; MINETT A. I. Characterisation of Graphene oxide and its derivatives, Scientific Reports, (2016).

CANÇADO L. G.; JORIO A.; FERREIRA E. H. M.; STAVALE F.; ACHETE C. A.; CAPAZ R. B.; MOUTINHO M. V. O.; LOMBARDO A.; KULMALA T.; FERRARI A. C. Quantifying defects in graphene via raman spectroscopy at different excitation energies, v.2, (2011).