Perfomance analysis of a small animal PET scanner using 68Ga Isotope

Autores/as

  • Victória Garcia Moreira Universidade Federal de Minas Gerais UFMG, Faculdade de Medicina, Departamento de Anatomia e Imagem
  • Anna Clara Moreira Silva Universidade Federal de Minas Gerais UFMG, Faculdade de Medicina, Departamento de Anatomia e Imagem
  • Rodrigo Modesto Gadelha Gontijo Universidade Federal de Minas Gerais image/svg+xml
  • Andréa Vidal Ferreira Centro de Desenvolvimento da Tecnologia Nuclear CDTN/CNEN 31.270-901, Belo Horizonte, Minas Gerais, Brazil

DOI:

https://doi.org/10.15392/2319-0612.2025.2844

Palabras clave:

PET, galium-68, Image Quality

Resumen

In recent years, the use of PET scanners for small animals in preclinical research has been growing in Brazil, due to this fact it is essential to have a quality assurance program to ensure the good performance of these scanners or indicate the need for corrective maintenance. In 2008, the National Association of Electrical Equipment Manufacturers (NEMA) in the USA published a document that proposes the following tests to ensure quality control: uniformity, spill-over ratio, and recovery coefficients. Thus, the objective of this work was to evaluate the image quality of the PET scanner for small animals LabPET SOLO 4 using the isotope Gallium-68. The results revealed that the use of the isotope 68Ga was quite different from standard tests using 18F. The project provided us with a comprehensive understanding of the functioning of the PET scanner when employing the radionuclide 68Ga. This evaluation is of crucial relevance for application in laboratories, especially in the quantitative analysis of PET images and in the planning of preclinical studies

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Referencias

[1] Silva, A.V.; Gontijo, R.M.G.; Ferreira, A.V. “Quality control in small animal pet scanners: analysis of the brazilian scenario in 2024.” in: Semana Nacional de Engenharia Nuclear e da Energia e Ciências das Radiações. Anais. Belo Horizonte (MG) UFMG, 2024. Available at: https//www.even3.com.br/anais/vii-sencir-semana-nacional-de-engenharia-nuclear-e-da-energia-e-ciencias-das-radiacoes-449507/913858-quality-control-in-small-animal-pet-scanners--analysis-of-the-brazilian-scenario-in-2024. Accessed on: 01/23/2025.

[2] Kleynhans J.; Ebenhan T.; Sathekge M. M.; Expanding Role for Gallium-68 PET Imaging in Oncology; Seminars in Nuclear Medicine ; V. 54, Issue 6, November 2024, P. 778-791 (2024).

[3] NEMA - National Electrical Manufacturers Association. Performance Measurements of Small Animal Positron Emission Tomographs; Rosslyn VA, Standards Publication NU 4-2008 (2008).

[4] Gontijo, R.M.G., “Image quality evaluation of a small animal PET scanner,” Brazilian Journal of Radiation Sciences, vol. 08-01, pp. 1–13 (2020).

[5] IGT Generator, “Instructions for Ge-68/Ga-68 Generator Operation”, Manufacturer's Manual Technical. Second Version (2015).

[6] CAPINTEC CRC 25® Owner´s Manual, Capintec. Inc, 7 Vreeland Road, 2017-05-09.

[7] Gontijo, R.M.G.; Ferreira, A.V.; SILVA, J.B.; LEWER, M. H. M. Estudo dos parâmetros de reconstrução em imagens MicroPET. In: XII Congresso SBBN, 2017, São Paulo. XII Congresso SBBN, (2017).

[8] Gontijo, R.M.G., “Image quality evaluation of a small animal PET scanner,” Brazilian Journal of Radiation Sciences, vol. 08-01, pp. 1–13 (2020).

[9] GE Healthcare Technologies, “Triumph Service Guide”, Technical Publication, 2011.

[10] AMIDE: Amide's a Medical Imaging Data Examiner, validate: CSS & HTML. Project hosted by: Source Forge. Last modified: 2012-10-17.

[11] BELCARI, N. et al. NEMA NU-4 Performance Evaluation of the IRIS PET/CT Preclincial Scanner. IEEE Transactions on Nuclear Science, 2017. v.1, n.4, p. 301-309.

[12] National Institute of Standards and Technology, Available in: https://www.nist.gov/pmL/radiation-dosimetry-data. (2025).

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Publicado

2025-06-27

Número

Vol. 13 Núm. 2 (2025)

Sección

Articles

Licencia

Derechos de autor 2025 Victória Garcia Moreira, Anna Clara Moreira Silva, Rodrigo Modesto Gadelha Gontijo, Andréa Vidal Ferreira

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

Licencia: los artículos de BJRS tienen una licencia internacional Creative Commons Attribution 4.0, que permite el uso, el intercambio, la adaptación, la distribución y la reproducción en cualquier medio o formato, siempre que se otorgue el crédito correspondiente al autor o autores originales y a la fuente, proporcione un enlace a la licencia Creative Commons e indique si se realizaron cambios. Las imágenes u otros materiales de terceros en el artículo están incluidos en la licencia Creative Commons del artículo, a menos que se indique lo contrario en una línea de crédito al material. Si el material no está incluido en la licencia Creative Commons del artículo y su uso previsto no está permitido por la regulación legal o excede el uso permitido, el autor deberá obtener el permiso directamente del titular de los derechos de autor. Para ver una copia de esta licencia, visite http://creativecommons.org/licenses/by/4.0/

Cómo citar

Perfomance analysis of a small animal PET scanner using 68Ga Isotope. Brazilian Journal of Radiation Sciences (BJRS), Rio de Janeiro, Brazil, v. 13, n. 2, p. e2844, 2025. DOI: 10.15392/2319-0612.2025.2844. Disponível em: https://bjrs.org.br/revista/index.php/REVISTA/article/view/2844. Acesso em: 17 jul. 2025.