Deconvolution method to split up X-ray peaks emitted by 223Ra
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https://doi.org/10.15392/bjrs.v6i1.353Palavras-chave:
X-Ray, Spectrometry, X-Ray Emission, Area Under Curve, 223Ra.Resumo
The Radium-223 (223Ra) has being used as a medicine for localized treatment of patients with osteoblastic metastasis originated by prostate cancer resistant of castration or hormone refractory. For a better treatment with this radionuclide, clinical images are one path to turn achievable organ's dosimetry for each patient. The X-rays emitted by 223Ra demonstrated as the main way to turn the image acquiring feasible. In order to study this X-ray area, deconvolution is necessary to split up the mains X-ray peaks that are measured by a high-purity germanium detector as doublet peaks in a complex region of the spectrum below 100 keV. For this, the Colegram® code was applied using the Low Energy X Voigt fitting curve on raw data source from Maestro® software. Results of activity using the deconvolution data from this work were in agreement with values obtained at absolute standardization live-time anticoincidence counting. The Colegram® code demonstrates a powerful tool to aid Maestro to split up the mains overlapped X-rays emitted by 223Ra.
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REFERENCES
ATKINS, H. L. Overview of nuclides for bone pain palliation. Applied radiation and isotopes, v. 49, n. 4, p. 277-283, 1998.
BELLMUNT, J. Tackling the bone with alpha emitters in metastatic castration-resistant prostate cancer patients. European urology, v. 63, n. 2, p. 198-200, 2013.
BRULAND, Ø. S. et al. High-linear energy transfer irradiation targeted to skeletal metastases by the α-emitter 223Ra: adjuvant or alternative to conventional modalities?. Clinical cancer research, v. 12, n. 20, p. 6250s-6257s, 2006.
CHECHEV, V. P., et al. Table of radionuclides (Vol. 6–A= 22 to 242). Monographie BIPM-5, Bureau International des Poids et Mesures, Sèvres, p.85-89, 2011.
COLLINS, S. M. et al. Direct measurement of the half-life of 223Ra. Applied Radiation and Iso-topes, v. 99, p. 46-53, 2015.
DA SILVA, C. J. et al. Standardization of 241Am, 124Sb and 131I by live-timed anti-coincidence counting with extending dead time. Applied Radiation and Isotopes, v. 66, n. 6, p. 886-889, 2008.
DELGADO, J. U.; MOREL, J.; ETCHEVERRY, M. Measurements of photon emission probabili-ties from the decay of 226Ra and daughters. Applied Radiation and Isotopes, v. 56, n. 1, p. 137-143, 2002.
EMA/CHMP - European medicines Agency/Committee for Medicinal Products for Human Use, Document EMA/CHMP/411215/2013, Summary of Opinion, Initial Authorization. 19 September 2013, Available at:
<http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/002653/WC500150073.pdf>. Last accessed: 15 sept. 2017.
FDA - Food and Drug Administration. FDA approves new drug for advanced prostate cancer. 2013, Available at:
<https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2013/203971Orig1s000ltr.pdf>
Last accessed: 15 sept. 2017.
FLUX, G. D. Imaging and dosimetry for radium-223: the potential for personalized treatment. The British Journal of Radiology, v. 90, n. 0, p. 20160748, 2017.
HENRIKSEN, G. et al. Significant antitumor effect from bone-seeking, α-particle-emitting 223Ra demonstrated in an experimental skeletal metastases model. Cancer research, v. 62, n. 11, p. 3120-3125, 2002.
KEIGHTLEY, J. et al. Standardization of 223Ra by liquid scintillation counting techniques and comparison with secondary measurements. Applied Radiation and Isotopes, v. 95, p. 114-121, 2015.
KVINNSLAND, Y.; SKRETTING, A.; BRULAND, Ø. S. Radionuclide therapy with bone-seeking compounds: Monte Carlo calculations of dose-volume histograms for bone marrow in trabecular bone. Physics in medicine and biology, v. 46, n. 4, p. 1149, 2001.
LÉPY, M.C. Presentation of the COLEGRAM software. Note Technique LNHB/04/26, Saclay, France, 2004.
LEWINGTON, V. J. Bone-seeking radionuclides for therapy. Journal of nuclear medicine, v. 46, n. 1 suppl, p. 38S-47S, 2005.
MADSEN, K., NIELSEN, H. B. and TINGLEFF, O. Methods for non-linear least squares prob-lems. 2004.p.24-28.
MAESTRO, I. I. Software Operator’s Manual. Maestro for Windows. Version 5.33. EG&G. ORTEC, 2002.
PACILIO, M. et al. A case report of image-based dosimetry of bone metastases with Alpharadin (223Ra-dichloride) therapy: inter-fraction variability of absorbed dose and follow-up. Annals of nuclear medicine, v. 30, n. 2, p. 163-168, 2016.
PARKER, C. et al. Alpha emitter radium-223 and survival in metastatic prostate cancer. New England Journal of Medicine, v. 369, n. 3, p. 213-223, 2013.
SÁNCHEZ-JIMÉNEZ, J. et al. 223 Ra-dichloride spectrometric characterization: Searching for the presence of long-lived isotopes with radiological protection implications. Physica Medica, v. 35, p. 97-101, 2017.
SUORTTI, P.; AHTEE, M.; UNONIUS, L. Voigt function fit of X-ray and neutron powder diffrac-tion profiles. Journal of Applied Crystallography, v. 12, n. 4, p. 365-369, 1979.
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