Synthesis and characterization of Au- 198 nanoparticles for radiotherapy
DOI:
https://doi.org/10.15392/2319-0612.2024.2753Palabras clave:
Gold nanoparticles, Nanobrachytherapy, Polyethylene glycol (PEG)Resumen
In recent years, rapid progress in nanotechnology has stimulated growing interest in nanoparticle research, particularly in the fight against cancer, a leading cause of death worldwide. Currently, gold nanoparticles (AuNPs) are being studied as an alternative to conventional cancer treatments, which, despite their effectiveness, face challenges such as side effects due to low selectivity. This work focuses on the synthesis of AuNPs functionalized with polyethylene glycol (PEG) in both their non-radioactive and radioactive forms and on their physicochemical properties. The AuNPs functionalized with PEG were produced using the adapted Turkevich method, and their physicochemical characteristics were analyzed using Dynamic Light Scattering with Zeta Sizer (DLS), UV-Vis spectroscopy, and transmission electron microscopy (TEM), assessing the effect of the amount of sodium citrate, as a reducing agent, on the size of the nanoparticles. The results showed a hydrodynamic diameter of 22.62 nanometers, a surface charge of - 0.1269mV, and an average size of 12.12nm as measured by TEM. The studies were conducted with radioactive gold-198 nanoparticles, and their presence was confirmed by an HPGe detector.
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Derechos de autor 2025 Maria Eduarda Zaganin Rigo, Angelica Bueno Barbezan, Cristhian Talacimon, Lara El Hajj Teodoro, Priscila Santos Rodrigues, Wilmer Alexander Arcos Rosero, Thuany Correa Nogueira, Maria Elisa Chuery Martins Rostelato
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Licencia: los artículos de BJRS tienen una licencia internacional Creative Commons Attribution 4.0, que permite el uso, el intercambio, la adaptación, la distribución y la reproducción en cualquier medio o formato, siempre que se otorgue el crédito correspondiente al autor o autores originales y a la fuente, proporcione un enlace a la licencia Creative Commons e indique si se realizaron cambios. Las imágenes u otros materiales de terceros en el artículo están incluidos en la licencia Creative Commons del artículo, a menos que se indique lo contrario en una línea de crédito al material. Si el material no está incluido en la licencia Creative Commons del artículo y su uso previsto no está permitido por la regulación legal o excede el uso permitido, el autor deberá obtener el permiso directamente del titular de los derechos de autor. Para ver una copia de esta licencia, visite http://creativecommons.org/licenses/by/4.0/
