Spatial resolution of a preclinical PET tomograph

Authors

  • Guilherme Cavalcante de Albuquerque Souza Centro de Desenvolvimento da Tecnologia Nuclear CDTN/CNEN
  • Rodrigo Modesto Gadelha Gontijo Faculdade de Medicina da UFMG
  • Juliana Batista da Silva Centro de Desenvolvimento da Tecnologia Nuclear CDTN/CNEN
  • Marcelo Mamede Faculdade de Medicina da UFMG
  • Andréa Vidal Ferreira Centro de Desenvolvimento da Tecnologia Nuclear CDTN/CNEN

DOI:

https://doi.org/10.15392/bjrs.v9i1A.1503

Keywords:

Spatial resolution, small animal PET scanner, image quality control.

Abstract

Positron emission tomography (PET) is an important molecular image modality and its application on preclinical research has increased during last decades. Thus, in laboratory practice, it is important to implement a quality control of the equipment, since intrinsic factors influence the image quality. The objective of this work was to perform and implement spatial resolution tests for the small animal PET scanner of the Molecular Imaging Laboratory, LIM/CDTN. Empirically, spatial resolution of a PET scanner can be determined from the measurement of point or linear sources and FWHM (full width half maximum) analysis of the respective linear profiles. In this work, a point source of 22Na and a hot rod style phantom filled with 18F-FDG solution were used. Acquisition and reconstruction of images were performed with the LabPET 1.12.1 software, provided by the equipment manufacturer. Image reconstruction parameters followed the LIM standard protocol: MLEM-3D algorithm, 20 iterations, no high resolution mode, no attenuation or scatter corrections, no post-filtering. PeakFit® and Amide softwares were used to perform images post-processing. The results indicate that the scanner has an adequate spatial resolution and its value is compatible with values reported in international studies performed on similar equipments.

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References

SAHA,G.B., “Basics of PET Imaging: Physics, Chemistry, and Regulations”, © Springer Science + Business Media, LLC, (2010).

. HEYU WU, et al, “Micro Insert: A Prototype Full-Ring PET Device for Improving the Image Resolution of a SmallAnimal PET Scanner”, The Journal of Nuclear Medicine,Vol. 10, pp 1668-1676, (2008)

GE HEALTHCARE, “Triumph Service Guide”, Technical Publication, © GE Healthcare, Revision Draft 6, USA (2011).

“Micro-PET Hot-Rod Phantom’’, http://www.qrm.de/content/pdf/QRM-MicroPET-Hot Rod.pdf (2018).

NEMA, National Electrical Manufacturers Association. “Performance Measurements Of Small Animal Pet”. Rosslyn VA; Standards Publication NU 4-(2008).

GONTIJO, R. M. G. et al., “Definição de protocolo padrão para reconstrução de imagem PET não clínica”, X Encontro Mineiro de Física (EMIF) e V Semana da Licenciatura em Física (SELFÍS), Salinas-MG. 2018.

DAHLE,T. J., “Performance Evaluation of a Small-Animal PET/CT System”, pp 28-29, (2014).

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Published

2021-04-30

How to Cite

Souza, G. C. de A., Gontijo, R. M. G., Silva, J. B. da, Mamede, M., & Ferreira, A. V. (2021). Spatial resolution of a preclinical PET tomograph. Brazilian Journal of Radiation Sciences, 9(1A). https://doi.org/10.15392/bjrs.v9i1A.1503

Issue

Section

The Meeting on Nuclear Applications (ENAN) 2019

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