Degradation and Toxicity of Amoxicillin After  Electron Beam Irradiation

Sueli  Ivone Borrely; Marcelo  Miyada Redígolo; Bruno David Quiroz Villardi; Daniel Temponi Lebre; Flavio Kiyoshi Tominaga

doi:10.15392/2319-0612.2022.1894

Degradation and Toxicity of Amoxicillin After Electron Beam Irradiation

Authors

Sueli Ivone Borrely
Marcelo Miyada Redígolo
Bruno David Quiroz Villardi
Daniel Temponi Lebre
Flavio Kiyoshi Tominaga IPEN

DOI:

https://doi.org/10.15392/2319-0612.2022.1894

Keywords:

Electron Beam Irradiation, Antibiotic, Toxicity

Abstract

A recent and growing concern in environmental studies is the presence of antibiotics in wastewater, which contributes to antimicrobial resistance building. Amoxicillin, according to the World Health Organization, is one of the most consumed antibiotics worldwide, for being a first line therapy for common infections. Among several drug degradation methodologies, electron beam irradiation (EBI) is presented as an efficient and green treatment. This work presents data on amoxicillin degradation via EBI. Ecotoxicity essays were performed employing Vibrio fischeri, carbon removal efficiency was evaluated by TOC and degradation rate by LC/MS-MS. Chromatographic results indicate a 97.9% drug concentration reduction after 0.75 kGy; TOC results indicate 10% carbon removal at 3.0 kGy; toxicity assays indicate 80% in removal of toxicity at 0.75 kGy and a decrease in efficiency with higher doses. In conclusion, results indicate the 0.75 kGy as most effective for drug removal employing EBI.

Views: 184
PDF Downloads: 119

Downloads

Download data is not yet available.

References

GITHINJI, L. J. M.; MUSEY, M. K.; ANKUMAH, R. O. Evaluation of the fate of ciprofloxacin and amoxicillin in domestic wastewater. Water Air Soil Pollut, v. 219, p. 191-201, 2011. DOI: https://doi.org/10.1007/s11270-010-0697-1

TROJANOWICZ, M.; BOJANOWSKA-CZAJKA, A.; CAPODAGLIO, A. G. Can radiation chemistry supply a high efficient AO(R)P process for organics removal from drinking and waste water? A review. Eviron Sci Pollut Res, v. 24, p. 20187-20208, 2017. DOI: https://doi.org/10.1007/s11356-017-9836-1

ZHU, F.; PAN, J.; ZOU, Q.; WU, M.; WANG, H.; XU., G. Electron beam irradiation of typical sulfonamide antibiotics in the aquatic environment: kinetics, removal mechanisms, degradation products and toxicity assessment. Chemosphere, v. 274, p. 129713, 2021. DOI: https://doi.org/10.1016/j.chemosphere.2021.129713

TAKACS, E.; WANG, J.; CHU, L.; TOTH, T.; KOVACS, K.; BEZSENYI, A.; SZABO, L.; HOMLOK, R.; WOJNAROVITS. L. Elimination of oxacillin, its toxicity and antibacterial activity by using ionizing radiation. Chemosphere, v. 286, p. 131467, 2021. DOI: https://doi.org/10.1016/j.chemosphere.2021.131467

TEGZE, A.; SAGI, G.; KOVACS, K.; HOMLOK, R.; TOTH, T.; MOHACSI-FARKAS, C.; WOJNAROVITS, L.; TAKACS, E. Degradation of fluoroquinolone antibiotics during ionizing radiation treatment and assessment of antibacterial activity, toxicity and biodegradability of the products. Radiat Phys Chem, v. 147, p. 101-105, 2018. DOI: https://doi.org/10.1016/j.radphyschem.2018.02.015

TOMINAGA, F. K.; SILVA, T. T.; BOIANI, N. F.; JESUS, J. M. S.; TEIXEIRA, A. C. S. C.; BORRELY, S. I. Is ionizing radiation effective in removing pharmaceuticals from wastewater? Eviron Sci Pollut Res, v. 28, p. 23975-23983, 2021. DOI: https://doi.org/10.1007/s11356-020-11718-8

WANG, J.; CHU, L. Irradiation treatment of pharmaceutical and personal care products (PPCPs) in water and wastewater: an overview. Radiat Phys Chem, v. 125, p. 56-64, 2016. DOI: https://doi.org/10.1016/j.radphyschem.2016.03.012

Downloads

Published

2022-12-04

How to Cite

Ivone Borrely, S., Miyada Redígolo, . M., David Quiroz Villardi, . B., Temponi Lebre, D., & Kiyoshi Tominaga, F. (2022). Degradation and Toxicity of Amoxicillin After Electron Beam Irradiation. Brazilian Journal of Radiation Sciences, 10(3B (Suppl.). https://doi.org/10.15392/2319-0612.2022.1894

Download Citation

Issue

Vol. 10 No. 3B (Suppl.) (2022): XV ENAN 2021

Section

INAC 2021_XV ENAN

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Licensing: The BJRS articles are licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/