Comparative analysis between radioactive seed localization and wire-guided for non-palpable breast cancer surgery

Hortência de Jesus Ferreira; Carlos Alberto Zeituni; Maria Eduarda Zaganin Rigo; Hamona Novaes dos Santos; Wilmmer Alexander Arcos Rosero; Guilherme Favato Alcantara; Maria Elisa Chuery Martins Rostelato

doi:10.15392/2319-0612.2022.1909

Authors

Hortência de Jesus Ferreira IPEN-CNEN/SP
Carlos Alberto Zeituni
Maria Eduarda Zaganin Rigo
Hamona Novaes dos Santos
Wilmmer Alexander Arcos Rosero
Guilherme Favato Alcantara
Maria Elisa Chuery Martins Rostelato

DOI:

https://doi.org/10.15392/2319-0612.2022.1909

Keywords:

Breast conserving surgery, Radioative seed localization, Wire guided localization

Abstract

The conservative surgery for impalpable breast cancer requires an intraoperative localization method that guides the identification and correct excision of the lesion. The aim of this study is to comparatively analyze two intraoperative breast localization technologies, wire guided localization (WGL) and radioactive seed localization (RSL), regarding their surgical efficacy through the outcomes of surgical margins, intraoperative re-excision, reoperation and recurrence. To this end, a systematic search was realized in databases for clinical trials that match with the study eligibility criteria. The selected studies were evaluated for their methodological quality; the data were then collected and quantitatively synthesized. The results comprised thirty-eight studies that match the eligibility criteria. The main outcomes reported demonstrating that the RSL is at least equivalent to the WGL in efficiency rates. These results confirm the method applicability for impalpable breast lesions surgery in an effective way, in addition to presenting organizational optimization of radiology and surgery services by allowing the surgery to be performed up to two months after seed implantation.

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References

Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). ABC do câncer: abordagens básicas para o controle do cancer. 6. ed. Rio de Janeiro, Brasil (2020).

Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). A situação do câncer de mama no Brasil: síntese de dados dos sistemas de informação. Rio de Janeiro, Brasil (2019).

Chan B. K. Y.; Wiseberg-Firtell J. A.; Jois R. H. S.; et al. Localization techniques for guided surgical excision of non‐palpable breast lesions. Cochrane Database of Systematic Reviews, (2015). DOI: https://doi.org/10.1002/14651858.CD009206.pub2

Moreira I. C.; Ventura S. R.; Ramos I.; et al. Preoperative localisation techniques in breast conservative surgery: A systematic review and meta-analysis. Surgical Oncology, vol. 35, pp. 351-373 (2020). DOI: https://doi.org/10.1016/j.suronc.2020.09.004

Dauway E. Innovative Diagnostics for Breast Cancer: New Frontiers for the New Millennium Using Radioactive Seed Localization, In : Surgical Forum: 85th Annual American College of Surgeons Clinic Congress, Chicago, vol. 50 (1999).

Higgins J. P. T.; Sterne J. A. C.; Savović J.; et al. A revised tool for assessing risk of bias in randomized trials. Cochrane Methods. Cochrane Database of Systematic Reviews 2016, Issue 10 (Suppl 1). dx.doi.org/10.1002/14651858.CD201601.

Sterne J. A.; Hernãn M. A.; Reeves B. C.; et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ 2016; 355 :i4919 doi:10.1136/bmj.i4919. DOI: https://doi.org/10.1136/bmj.i4919

McGuinness L.A.; Higgins J.P.T. Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Res Syn Meth. 2020; 1- 7. https://doi.org/10.1002/jrsm.1411 DOI: https://doi.org/10.1002/jrsm.1411

Page M. J.; McKenzie J. E.; et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71. Doi: 10.1136/bmj.n71. DOI: https://doi.org/10.1136/bmj.n71

Bloomquist E. V ; Ajkay N.; Patil S.; et al. A Randomized Prospective Comparison of Patient-Assessed Satisfaction and Clinical Outcomes with Radioactive Seed Localization versus Wire Localization. The Breast Journal, Volume 22 Number 2, 2016 151–157 . DOI: 10.1111/tbj.12564. DOI: https://doi.org/10.1111/tbj.12564

Fung F.; Cornacchi S. D.; Reedijk M.; et al. Breast cancer recurrence following radioguided seed localization and standard wire localization of nonpalpable invasive and in situ breast cancers: 5-Year follow-up from a randomized controlled Trial. The American Journal of Surgery xxx (2016) 1e7. Doi: 10.1016/j.amjsurg.2016.06.016. DOI: https://doi.org/10.1016/j.amjsurg.2016.06.016

Gray R. J.; Salud C.; Nguyen K.; et al. Randomized Prospective Evaluation of a Novel Technique for Biopsy or Lumpectomy of Nonpalpable Breast Lesions: Radioactive Seed Versus Wire Localization. Annals of Surgical Oncology, 8(9):711–715. DOI: https://doi.org/10.1007/s10434-001-0711-3

Langhans L.; Tvedskov T. F.; Klausen T. L.; et al. Radioactive Seed Localization or Wire-guided Localization of Nonpalpable Invasive and In Situ Breast Cancer. Annals of Surgery, Volume 266, Number 1, July 2017. DOI: https://doi.org/10.1097/SLA.0000000000002101

Lovrics P. J.; Goldsmith C. H.; Hodgson N.; et al. A Multicentered, Randomized, Controlled Trial Comparing Radioguided Seed Localization to Standard Wire Localization for Nonpalpable, Invasive and in situ Breast Carcinomas. Ann Surg Oncol (2011) 18:3407–3414. DOI 10.1245/s10434-011-1699-y. DOI: https://doi.org/10.1245/s10434-011-1699-y

Taylor D. B.; Bourke A. G.; Westcott E. J.; et al. Surgical outcomes after radioactive 125I seed versus hookwire localization of non-palpable breast cancer: a multicentre randomized clinical Trial. BJS, 2021, 108, 40–48. DOI: 10.1093/bjs/znaa008. DOI: https://doi.org/10.1093/bjs/znaa008

Agahoso M. C.; Berghuis S. A. M.; van den Broek E.; et al. Radioactive Seed Versus Wire-Guided Localization for Ductal Carcinoma in Situ of the Breast: Comparable Resection Margins. Ann Surg Oncol. Doi: 10.1245/s10434-020-08744-8. DOI: https://doi.org/10.1245/s10434-020-08744-8

Aljohani B.; Jumaa K.; Kornecki A.; et al. Clinical utility of radioactive seed localization in nonpalpable breast cancer: A Retrospective single institutional cohort study. International Journal of Surgery. Doi:10.1016/j.ijsu.2018.11.004. DOI: https://doi.org/10.1016/j.ijsu.2018.11.004

Angarita F. A.; Acuna S. A.; Down N.; et al. Comparison of Radioactive Seed Localized Excision and Wire Localized Excision of Breast Lesions: A Community Hospital’s Experience. Clinical Breast Cancer. 1526-8209. Doi: 10.1016/j.clbc.2019.01.001. DOI: https://doi.org/10.1016/j.clbc.2019.01.001

Arnau I. M.; Sanchez R. S.; Casas M. C.; et al. Surgical clips vs. iodine-125 (125I) seeds for marking the location of nonpalpable malignant breast lesions: preliminary results. Radiología. 2020;62(1):38-45. DOI: https://doi.org/10.1016/j.rxeng.2019.08.002

Chiu J. C.; Ajmal S.; Zhu X.; et al. Radioactive Seed Localization of Nonpalpable Breast Lesions in an Academic Comprehensive Cancer Program Community Hospital Setting. The american surgeon. July 2014 Vol. 80. DOI: https://doi.org/10.1177/000313481408000722

Diego E. J.; Soran A.; McGuire K. P.; et al. Localizing High-Risk Lesions for Excisional Breast Biopsy: A Comparison Between Radioactive Seed Localization and Wire Localization. Ann Surg Oncol (2014) 21:3268–3272. DOI: 10.1245/s10434-014-3912-2. DOI: https://doi.org/10.1245/s10434-014-3912-2

Dryden M. J.; Dogan B. E.; Fox P.; et al. Imaging Factors That Influence Surgical Margins After Preoperative 125I Radioactive Seed Localization of Breast Lesions: Comparison With Wire Localization. AJR 2016; 206:1112–1118. DOI: https://doi.org/10.2214/AJR.15.14715

Gray R. J.; Pockaj B. A.; Karstaedt P. J.; et al. Radioactive seed localization of nonpalpable breast lesions is better than wire localization. The American Journal of Surgery 188 (2004) 377–380. DOI: https://doi.org/10.1016/j.amjsurg.2004.06.023

Horwood C. R.; Grignol V.; Lahey S.; et al. Radioactive seed vs wire localization for nonpalpable breast lesions: A single institution review. Breast J. 2019;1–4. DOI: 10.1111/tbj.13201. DOI: https://doi.org/10.1111/tbj.13201

Hout B. A.; Schenk K. E. van der Linden A. N.; et al. Efficacy of localization of non-palpable, invasive breast cancer: Wire localization vs. Iodine-125 seed: A historical comparison. The Breast 29 (2016) 8e13. Doi: 10.1016/j.breast.2016.06.011. DOI: https://doi.org/10.1016/j.breast.2016.06.011

Hughes J. H.; Mason M. C.; Gray R. J.; et al. A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization. The Breast Journal, Volume 14 Number 2, 2008 153–157. DOI: https://doi.org/10.1111/j.1524-4741.2007.00546.x

Jumaa K.; Aljohani B.; Brackstone M.; et al. A Single-Institute Experience With Radioactive Seed Localization of Breast Lesions—A Retrospective Study. Canadian Association of Radiologists Journal 2020, Vol. 71(1) 58-62. DOI: 10.1177/0846537119885682. DOI: https://doi.org/10.1177/0846537119885682

Law W.; Cao X.; Wright F. C.; et al. Adequacy of invasive and in situ breast carcinoma margins in radioactive seed and wire-guided localization lumpectomies. Breast J. 2020;00:1–7. DOI: 10.1111/tbj.14115. DOI: https://doi.org/10.1111/tbj.14115

Luiten J. D.; Beek M. A.; Voogd A. C.; et al. Iodine seed- versus wire-guided localization in breast-conserving surgery for non-palpable ductal carcinoma in situ. BJS 2015; 102: 1665–166. DOI: https://doi.org/10.1002/bjs.9946

Miligan R.; Pieri A.; Critchley A.; et al. Radioactive seed localization compared with wireguided localization of non-palpable breast carcinoma in breast conservation surgery— the first experience in the United Kingdom. BJ Radiol 2018; 91: 20170268. DOI: https://doi.org/10.1259/bjr.20170268

Murphy J. O.; Moo T.; King T. A.; Radioactive Seed Localization Compared to Wire Localization in Breast-Conserving Surgery: Initial 6-Month Experience. Ann Surg Oncol (2013) 20:4121–4127. DOI 10.1245/s10434-013-3166-4. DOI: https://doi.org/10.1245/s10434-013-3166-4

Murphy B. L.; Boughey J. C.; Keeney M. G.; et al. Factors Associated With Positive Margins in Women Undergoing Breast Conservation Surgery. Mayo Clin Proc. n XXX 2017;nn(n):1-7 n. Doi10.1016/j.mayocp.2017.11.023

Parvez E.; Cornachi S. D.; Fu E.; et al. Adoption and outcomes of radioguided seed localization for nonpalpable invasive and in-situ breast cancer at three academic tertiary care centers. The American Journal of Surgery xxx (2018) 1e6. Doi: 10.1016/j.amjsurg.2018.07.007. DOI: https://doi.org/10.1016/j.amjsurg.2018.07.007

Pieri A.; Milligan R.; Critchley A.; et al. The introduction of radioactive seed localisation improves the oncological outcome of image guided breast conservation surgery. The Breast 36 (2017) 49e53. Doi:10.1016/j.breast.2017.09.004. DOI: https://doi.org/10.1016/j.breast.2017.09.004

Rao R.; Moldrem A.; Sarode V.; et al. Experience with Seed Localization for Nonpalpable Breast Lesions in a Public Health Care System. Ann Surg Oncol (2010) 17:3241–3246. DOI: 10.1245/s10434-010-1139-4. DOI: https://doi.org/10.1245/s10434-010-1139-4

Rarick J.; Kimler B. F.; Tawmfik O. Comparison of margin status and lesional size between radioactive seed localized vs conventional wire localized breast lumpectomy specimens. Annals of Diagnostic Pathology 21 (2016) 47–52. DOI: https://doi.org/10.1016/j.anndiagpath.2016.01.003

Sanchez R. S.; Jiménez A. D. G.; Aguirre A. C. R.; et al. 125I radioactive seed localization for non-palpable lesions in breast cancer. Rev Esp Med Nucl Imagen Mol. 2019;xxx(xx):xxx–xxx.

Saphier N.; Kondraciuk J.; Morris E.; et al. Preoperative Localization of Breast MRI Lesions: MRI-guided Marker Placement With Radioactive Seed Localization as an Alternative to MRI-guided Wire Localization. Journal of Breast Imaging, 2020, Vol. 2, Issue 3, 250–258. Doi:10.1093/jbi/wbaa012. DOI: https://doi.org/10.1093/jbi/wbaa012

Sharek D.; Zuley M. L.; Zhang J. Y.; et al. Radioactive seed localization versus wire localization for lumpectomies: a comparison of outcomes. AJR 2015; 204:872–877. DOI:10.2214/AJR.14.12743. DOI: https://doi.org/10.2214/AJR.14.12743

Silva M.; Porembka J.; Mokdad A. A.; et al. Bracketed radioactive seed localization vs bracketed wire-localization in breast surgery. Breast J. 2017;1–6. DOI: 10.1111/tbj.12854. DOI: https://doi.org/10.1111/tbj.12854

Srour M. K.; Kim S.; Amersi F.; et al. Comparison of wire localization, radioactive seed, and Savi scout radar for management of surgical breast disease. Breast J. 2019;00:1–8. DOI: 10.1111/tbj.13499. DOI: https://doi.org/10.1111/tbj.13499

Srour M. K.; Kim S.; Amersi F.; et al. Comparison of Multiple Wire, Radioactive Seed, and Savi Scout_ Radar Localizations for Management of Surgical Breast Disease. Ann Surg Oncol. Doi: 10.1245/s10434-020-09159-1. DOI: https://doi.org/10.1245/s10434-020-09159-1

Stelle L.; Schoenheit T.; Brubaker A.; et al. Radioactive Seed Localization Versus Wire Localization for Nonpalpable Breast Lesions: A Two-Year Initial Experience at a Large Community Hospital. Ann Surg Oncol. Doi: 10.1245/s10434-017-6102-1. DOI: https://doi.org/10.1245/s10434-017-6102-1

Theunissen C. I. J. M.; Rust E. A. Z.; Edens M. A.; et al. Radioactive seed localization is the preferred technique in nonpalpable breast cancer compared with wire-guided localization and radioguided occult lesion localization. Nuclear medicine communications. DOI: 10.1097/MNM.0000000000000659. DOI: https://doi.org/10.1097/MNM.0000000000000659

Tran V. T.; David J.; Patocskai E.; et al. Comparative Evaluation of Iodine-125 Radioactive Seed Localization and Wire Localization for Resection of Breast Lesions. Canadian Association of Radiologists Journal xx (2017) 1e9. Doi:10.1016/j.carj.2017.04.006 DOI: https://doi.org/10.1016/j.carj.2017.04.006

Zenzola V.; Hidalgo F.; Paredes R.; et al. Estudio comparativo entre radiolocalización con aguja arpón y uso de semillas radioactivas de yodo125 en lesiones subclínicas de mama. Rev Venez Oncol 2006;18(3):136-143.

Zhang Y.; Seely J.; Cordeiro E.; et al. Radioactive Seed Localization Versus Wire-Guided Localization for Nonpalpable Breast Cancer: A Cost and Operating Room Efficiency Analysis. Ann Surg Oncol DOI: 10.1245/s10434-017-6084-z. DOI: https://doi.org/10.1245/s10434-017-6084-z

Gobardhan P. D.; Wall L. L.; van der Laan L.; et al. The role of radioactive iodine-125 seed localization in breast-conserving therapy following neoadjuvant chemotherapy. Annals of Oncology, vol. 24, pp. 668-673 (2013). DOI: https://doi.org/10.1093/annonc/mds475

Institute national d’excellence em santé et em services sociaux (INESSS). Utilisation de la bille radioactive pour la localization préopératoire de tumeurs mammaires non palpables. Québec, Qc: INESSS (2015).