Proposal of Brazilian National Program for Quality Control in the small animal PET scanners

Authors

DOI:

https://doi.org/10.15392/2319-0612.2022.1978

Keywords:

preclinical PET, Quality Control Program, NEMA NU 4-2008

Abstract

In Brazil, currently there are six preclinical molecular imaging centers and seven different small animal PET systems in use. However, there is still no national specific legislation for research laboratories focused on preclinical molecular images, unlike clinical nuclear medicine centers. A standardization of quality control protocols is needed to harmonize the use of small animal PET scanners in the research field. Thus, the aim of this work was to propose a National Program for Quality Control (NPQC) for the preclinical PET imaging systems in Brazil. This work was based on the quality control tests performed in Molecular Image Laboratory LIM/CDTN based on NEMA NU 4-2008 as described and presented in doctoral thesis of GONTIJO, 2019. The proposal of the NQCP was based on the CNEN NN 3.05 Publication (2013) and includes fundamental tests to be adopted, if possible, in laboratory practice to corroborate the experimental data. The Quality Control Program implemented in LIM/CDTN is an innovative and unprecedented proposal in the scope of preclinical molecular imaging services in Brazil. Therefore, the LIM/CDTN Program was carried out as a pilot to evidence the applicability and viability of the NQCP using small animal PET scanners. Summarizing, this work presents a viable set of Quality Control tests and their periodicities like a proposal for standardization to harmonize the use of this imaging technology in the field of research. Therefore, a National Quality Control Program (NQCP) applied to small animal PET scanners.

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References

YAO R.; LECOMTE R.; CRAWFORD E. Small-Animal PET: What is it, and why do we need it? Journal of Nuclear Medicine Technology. Vol. 40 nº3, pp.157-165. 2011. DOI: https://doi.org/10.2967/jnmt.111.098632

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IAEA - International Atomic Energy Agency (IAEA). Quality Control Guidance for Nuclear Medicine Equipment. Guidelines of Radiation and Nuclear Safety Authority – STUK, 2010.

CNEN - Comissão Nacional de Energia Nuclear. Requisitos de segurança e proteção radioló-gica para serviços de medicina nuclear, Norma CNEN NN 3.05. December 2013.

GONTIJO, R. M. G. Proposta de Programa de Garantia da Qualidade para Imagem Mole-cular Pré-Clínica. 2019. 275 f. Doctoral Thesis (Doutorado em Ciência e Tecnologia das Radi-ações, Minerais e Materiais) – Centro de Desenvolvimento da Tecnologia Nuclear, Comissão Nacional de Energia Nuclear, Belo Horizonte, In Portuguese, 2019.

GONTIJO, R. M. G., FERREIRA, A. V., SILVA, J. B., MAMEDE, M. Quality control of small animal PET scanner: The Brazilian Scenario. Brazilian Journal of Radiation Sciences. vol. 08 (2). pp. 1-09. 2020.

GONTIJO, R. M. G., FERREIRA, A. V., SOUZA, G. C. A., BARBOSA, J. V. C., MAMEDE, M. Current Brazilian Scenario about Quality Assurance in preclinical PET imaging systems. 2021 International Nuclear Atlantic Conference – INAC 2021 Virtual meeting, Brazil, November 29 – December 2, 2021.

GONTIJO, R. M. G., FERREIRA, A. V., SILVA, J. B., MAMEDE, M. Image quality assess-ment using NEMA NU 4/2008 standards in small animal PET scanner. Brazilian Journal of Radiation Sciences. 07 (2A). pp. 1-13. 2019. DOI: https://doi.org/10.15392/bjrs.v7i2A.580

OSBORNE, D. R., KUNTNER, C., BERR, S., STOUT, D. Guidance for Efficient Small Ani-mal Imaging Quality Control. Molecular Imaging and Biology. 19 pp. 485-498. 2016. DOI: https://doi.org/10.1007/s11307-016-1012-3

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Published

2022-12-04

How to Cite

Gontijo, R. M. G. (2022). Proposal of Brazilian National Program for Quality Control in the small animal PET scanners . Brazilian Journal of Radiation Sciences, 10(3B (Suppl.). https://doi.org/10.15392/2319-0612.2022.1978

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Section

INAC 2021_XV ENAN

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