Gamma radiation in association with moderate training reduce the effects of asthma in mice

Nayara Alves Severo; Cilene Souza Barreto; Maria de Lourdes Meirelles Noviello; João Aguiar Nogueira Batista; Rosiane Resende Leite; Arno Heeren de Oliveria

doi:10.15392/bjrs.v10i3.2068

Authors

Nayara Alves Severo Departamento de Ciências da Saúde - Universidade Estadual de Santa Cruz, BA, Brasil
Cilene Souza Barreto Departamento de Ciências da Saúde - Universidade Estadual de Santa Cruz, BA, Brasil
Maria de Lourdes Meirelles Noviello Laboratório de Patologia e Imunologia – Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brasil https://orcid.org/0000-0001-5831-5054
João Aguiar Nogueira Batista Laboratório de Patologia e Imunologia – Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brasil
Rosiane Resende Leite Centro Federal de Educação Tecnológica de Minas Gerais, MG, Brasil
Arno Heeren de Oliveria Departamento de Engenharia Nuclear, Universidade Federal de Minas Gerais ,MG, Brasil https://orcid.org/0000-0001-7783-3041

DOI:

https://doi.org/10.15392/bjrs.v10i3.2068

Keywords:

Effects of radiation, Immune system, , Histological analysis

Abstract

Ionizing radiation has been used for the treatment of various diseases for over a century, including chronic inflammatory diseases and cancer. The relationship between radiation and asthma are contradictory; while some authors associate radiation exposure with the development of the disease, others report an attenuation of asthma in response to radiation. Asthma is a chronic inflammatory disease and represents a worldwide public health problem with a high number of deaths. In the present study, we have conducted an investigation of the effects of radiation with 10 doses of 0.5Gy of Co⁶⁰ and/or moderate lung training of mice with ovalbumin-induced asthma. For this purpose, we have compared six experimental groups of mice: 1-Saline (non-irradiated, sedentary and saline); 2- IR (irradiated and sedentary); 3- OVA (non-irradiated, sedentary and asthma); 4- OVA+IR (irradiated, asthma and sedentary); 5- OVA+IR+MT (irradiated, asthma and moderate training -TM); 6- OVA+MT (asthma and moderate training). The results indicate that radiation and moderate training reduced inflammatory parameters significantly both in BALF cells and in mucus production, thus attenuating the asthma symptoms.

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