Detection limit calculation according to ISO 11929 for in vitro 210Pb radiobioassay determinations by LSC

C. S. Sampaio; M. M. Martins; W. O. Sousa

doi:10.15392/2319-0612.2023.2185

Detection limit calculation according to ISO 11929 for in vitro 210Pb radiobioassay determinations by LSC

Authors

Camilla da Silva Sampaio DIDOS/IRD/CNEN https://orcid.org/0000-0002-1692-1328
Marcelo Marques Martins DIDOS/IRD/CNEN https://orcid.org/0000-0002-6817-9137
Wanderson de Oliveira Sousa DIDOS/IRD/CNEN https://orcid.org/0000-0001-9006-7417

DOI:

https://doi.org/10.15392/2319-0612.2023.2185

Keywords:

detection limit, 210Pb, LSC

Abstract

According to the limit of detection (DL) presented in ISO 11929:2010, the International Organization for Standardization (ISO) abandoned the concept of minimum detectable amount (MDA) described in ISO 12790-1:2001. In this work we demonstrate and discuss how we calculate the detection limit for the determination of ²¹⁰Pb by liquid scintillation counter (LSC) for the previously developed methodology and compare its results with the MDA value. The DL value found was 0.033 Bq/L instead of 0.032 Bq/L for MDA. The MDA and LD values did not differ virtually, the results highlight that the main change between the two Standard is related to the definition approach.

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References

ISO 12790-1:2001. Performance criteria for radiobioassay — Part 1: General principles. <https://www.iso.org/standard/32473.html>

ISO 11929:2010. Determination of the characteristic limits (decision threshold, detection limit and limits of the confidence interval) for measurements of ionizing radiation — Fundamentals and application. < https://www.iso.org/standard/43810.html>

ISO 28218:2010. Performance criteria for Radiobioassay. <https://www.iso.org/standard/40869.html>

SAMPAIO, C.S.; MEDEIROS, G.C.O.; MESQUITA, S.A.; DANTAS, B.M.; SOUSA, W.O. A new approach for the determination of 210Pb by liquid scintillation counting. Appl. Radiat. Isot. 156 108972, 2020. < https://doi.org/10.1016/j.apradiso.2019.108972> DOI: https://doi.org/10.1016/j.apradiso.2019.108972

Avaliação de dados de medição: Guia para a expressão de incerteza de medição – GUM 2008. Duque de Caxias, RJ: INMETRO/CICMA/SEPIN, 2012, 141 p. < https://www.gov.br/inmetro/pt-br/centrais-de-conteudo/publicacoes/documentos-tecnicos-em-metrologia/gum_final.pdf/view>

CURRIE, L. Limits for Qualitative Detection and Quantitative Determination. Anal. Chem. 40; pp. 586-593, 1968 < https://doi.org/10.1021/ac60259a007> DOI: https://doi.org/10.1021/ac60259a007

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Published

2023-03-29

How to Cite

Sampaio, C. S., Martins, M. M., & Sousa, W. O. (2023). Detection limit calculation according to ISO 11929 for in vitro 210Pb radiobioassay determinations by LSC. Brazilian Journal of Radiation Sciences, 11(1A (Suppl.), 1–9. https://doi.org/10.15392/2319-0612.2023.2185

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Issue

Vol. 11 No. 1A (Suppl.) (2023): RADIO 2022

Section

Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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