An easy and direct protocol based on planar molecular images to quantify 131I using thyroid phantom

Danny Giancarlo Apaza-Veliz; Vinicus Fernando dos Santos; Daniel Luis Franze; Wilson Furlan Matos Alves; Eder Rezende Moraes

doi:10.15392/2319-0612.2023.2325

Authors

Danny Giancarlo Apaza-Veliz University of São Paulo / Universidad Nacional de San Agustin de Arequipa https://orcid.org/0000-0001-7645-2626
Vinicus Fernando dos Santos University of São Paulo / Barretos Cancer Hospital https://orcid.org/0000-0002-3691-7799
Daniel Luis Franze University of São Paulo
Wilson Furlan Matos Alves Barretos Cancer Hospital
Eder Rezende Moraes University of São Paulo https://orcid.org/0000-0001-6889-3181

DOI:

https://doi.org/10.15392/2319-0612.2023.2325

Keywords:

radionuclide imaging, nuclear medicine, radiologic phantom, thyroid gland, iodine therapy

Abstract

A planar nuclear medicine image can be used to estimate dosimetry during iodine therapy. To this end, radionuclide activity distribution should be quantified in the patient’s body in terms of a calibration coefficient. This coefficient allows the net counts to correlate with the image’s activity. This study aims propose a simple and easy calibration protocol to quantify ¹³¹I activity in thyroid phantom by molecular planar images. Were acquired 13 planar images of different phantoms: thyroid phantom of symmetrical lobes; thyroid phantom of asymmetrical lobes; the Jacszack cylinder phantom with a syringe surrounded by air and water, and finally a plastic bottle containing a syringe with radionuclide. We applied the ¹³¹I radionuclide in a General Electric gamma camera, model Discovery NM/CT 670 with a high energy general purpose parallel hole collimator above the phantoms positioned at camera bed. The calibration coefficient of the gamma camera and the standard deviation were determined for each phantom; the average calibration coefficient obtained was 0.062±0.006 MBq/cps. The results suggested that the phantoms applied as too the calibration coefficient obtained by them can provides reasonable value for the gamma camera calibration factor for iodine 131, therefore an accurate evaluation of the scattering media as the source detector distance could impose higher variability and uncertainties on results.

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