Development of a methodology for the analysis of radionuclide impurities in radiopharmaceuticals by gamma-ray spectrometry

Authors

  • Eduardo Bonfim De Paula Instituto de Rádioproteção e Dosimetria IRD/CNEN
  • Miriam Tainá Ferreira de Araújo Programa de Engenharia Nuclear - PEN/COPPE/UFRJ
  • Roberto Poledna Instituto de Rádioproteção e Dosimetria IRD/CNEN
  • José Ubiratan Delgado Instituto de Rádioproteção e Dosimetria IRD/CNEN
  • Anderson Leiras Instituto de Rádioproteção e Dosimetria IRD/CNEN

DOI:

https://doi.org/10.15392/bjrs.v5i3.300

Keywords:

Radiopharmaceuticals, Radionuclide Impurities, Radionuclide Metrology.

Abstract

LNMRI has sought to develop a methodology for the identification and accurate detection of impurities emitting gamma radiation at the metrological level, aiming to meet the recommendations not only of the international pharmacopoeia, but also of CNEN and ANVISA regarding quality control that can ensure patients That the doses received by the practices are as low as practicable. As an initial goal, it was possible to obtain an efficiency curve with uncertainty around 1% necessary to start future measurements of interest applied to nuclear medicine and to begin the development of the impurities analysis technique.

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Author Biographies

Eduardo Bonfim De Paula, Instituto de Rádioproteção e Dosimetria IRD/CNEN

Laboratório Nacional de Metrologia das Radiações Ionizantes LMNRI/IR/CNEND

Miriam Tainá Ferreira de Araújo, Programa de Engenharia Nuclear - PEN/COPPE/UFRJ

Laboratório de Instrumentação Nuclear LIN/COPPE

Laboratório Nacional de Metrologia das Radiações Ionizantes LMNRI/IR/CNEND

Roberto Poledna, Instituto de Rádioproteção e Dosimetria IRD/CNEN

Laboratório Nacional de Metrologia das Radiações Ionizantes LMNRI/IR/CNEND

José Ubiratan Delgado, Instituto de Rádioproteção e Dosimetria IRD/CNEN

Laboratório Nacional de Metrologia das Radiações Ionizantes LMNRI/IR/CNEND

Anderson Leiras, Instituto de Rádioproteção e Dosimetria IRD/CNEN

Laboratório Nacional de Metrologia das Radiações Ionizantes LMNRI/IR/CNEND

References

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L. Carballo Silva, F. Campos Añón, M.A. Roque Alegre, C. Santos Montero, M. Martínez Seguer, M.N. Campos Llamazares, E. Marcos Segura, F. Pons Pons, 2014. Determinación de

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Published

2017-11-22

How to Cite

De Paula, E. B., de Araújo, M. T. F., Poledna, R., Delgado, J. U., & Leiras, A. (2017). Development of a methodology for the analysis of radionuclide impurities in radiopharmaceuticals by gamma-ray spectrometry. Brazilian Journal of Radiation Sciences, 5(3-A). https://doi.org/10.15392/bjrs.v5i3.300

Issue

Section

III Brazilian Congress on Metrology of Ionizing Radiation

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