SEMIQUANTITATIVE EVALUATION OF 99MTCTRODAT1 BINDING POTENTIAL BY TWO METHODS OF SPECT IMAGE RECONSTRUCTION.

Melissa Furlaneto Lellis Leite; Marilia Alves dos Reis; Cássio Miri Oliveira; Mario Luiz Vieira Castiglioni; Rodrigo Affonseca Bressan

doi:10.15392/bjrs.v7i2A.638

Authors

Melissa Furlaneto Lellis Leite Universidade Federal de São Paulo - UNIFESP
Marilia Alves dos Reis Universidade Federal de São Paulo - UNIFESP
Cássio Miri Oliveira Universidade Federal de São Paulo - UNIFESP
Mario Luiz Vieira Castiglioni Universidade Federal de São Paulo - UNIFESP
Rodrigo Affonseca Bressan Universidade Federal de São Paulo - UNIFESP

DOI:

https://doi.org/10.15392/bjrs.v7i2A.638

Keywords:

SPECT, TRODAT-1, OSEM, , Filtered Back Projection, Dopamine Transporter

Abstract

TRODAT-1 is a radiopharmaceutical derived from tropane and linked to tecnecium-99m ([^99mTc] TRODAT-1) has been used in studies of dopamine transporter (DAT) in central nervous system. Associated with the SPECT technique of acquisition, is able to detect changes in neurological disorders like Parkinson´s disease, evaluating the binding potential (BP) of DAT. The aim of this study was to evaluate the influence of the image reconstruction methods, Filtered Back Projection (FBP) and iterative reconstruction (OSEM), in BP values at the striatal region in 30 healthy volunteers. Images were analyzed by visual inspection and semi-quantitative analysis. Regions of interest (ROI) were made over striatal areas on both sides. Nonparametric Wilcoxon statistical analysis was performed between the BP values from the FBP and OSEM methods. Our results showed that the reconstruction methods have a statistical significant BP values difference in the total striatum (Z = -2,2787 p = 0.005), right striatum (Z = -2,602 p = 0.009) and left striatum (Z= 2,746 p = 0.006). The effect size was calculated to see if there influence in this test: the "large effect size" for all measurements was observed (total striatum r= -0.51; right striatum r= -0.48; left striatum r= -0.50). FBP is the usual method of reconstruction for brain SPECT images, and our results showed influence of the OSEM method in BP. It is concluded that the method of image reconstruction adopted should be standardized to avoid incorrect evaluations of BP values using [^99mTc]TRODAT-1.

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Author Biographies

Melissa Furlaneto Lellis Leite, Universidade Federal de São Paulo - UNIFESP

Biomédica do Departamento de Diagnóstico por Imagem da Universidade Federal de São Paulo - DDI UNIFESP

Marilia Alves dos Reis, Universidade Federal de São Paulo - UNIFESP

Biomédica do Departamento de Diagnóstico por Imagem da Universidade Federal de São Paulo - DDI UNIFESP; Mestre em Ciências; Doutorado em andamento pelo Departamento de Psiquiatria da Universidade Federal de São Paulo - UNIFESP

Cássio Miri Oliveira, Universidade Federal de São Paulo - UNIFESP

Professor Adjunto do Departamento de Diagnóstico por Imagem da Universidade Federal de São Paulo - DDI UNIFESP

Mario Luiz Vieira Castiglioni, Universidade Federal de São Paulo - UNIFESP

Médico Nuclear do Departamento de Diagnóstico por Imagem da Universidade Federal de São Paulo - DDI UNIFESP

Rodrigo Affonseca Bressan, Universidade Federal de São Paulo - UNIFESP

Professor Livre Docente do Departamento de Psiquiatria da Universidade Federal de São Paulo - UNIFESP

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