Uma revisão crítica dos processos de translação em radioterapia pre-clínica associada às limitações na dosimetria de irradiadores biológicos conformacionais
DOI:
https://doi.org/10.15392/bjrs.v7i3.883Keywords:
Radioterapia pre-clínica, irradiação pequenos animais, SARRP, dosimetria campos pequenos kVAbstract
A radioterapia é reconhecida como uma das principais modalidades para o tratamento do câncer no mundo, a translação dos resultados das pesquisas pré-clínicas para ensaios clínicos representa uma otimização dos recursos destinados ao combate desta doença. O aperfeiçoamento nas limitações dosimétricas relacionadas ao desenvolvimento dos estudos de radiobiologia assim como uma correta divulgação dos resultados e descobertas podem nos permitir estreitar o gap entre a pesquisa pré-clínica e a clínica. Neste trabalho, apresentamos, através de uma revisão bibliográfica, as características das informações relatadas nos estudos pré-clínicos envolvendo radiações ionizantes e relações dose-resposta. Estas informações são correlacionadas com o impacto na aplicabilidade dos resultados dentro dos conceitos da radioterapia clínica. Apresentamos também a evolução das propostas dosimétricas para irradiadores biológicos conformacionais de pequenos animais, com feixes de fótons de dimensões de campo de radiação milimétricos e energias de até 225 kVp, principalmente para o sistema SARRP (Small animal radiation research platform). As propostas para dosimetria de referência e relativa para campos pequenos, próximos aos 5mm de diâmetro, são atualmente escassas para a referida faixa energética. Este trabalho tem como ojetivo evidenciar a necessidade de novas propostas dosimétricas neste campo de estudo com o mesmo rigor metrológico requerido na radioterapia clínica.
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References
WHO-World Health Organization. World Health Statistics 2017: Monitoring health for the Sustainable Development Goals SDGs. World Health Organization, 2017.
FREEDMAN, L. P.; COCKBURN, I. M.; SIMCOE, T. S. The Economics of Reproducibility in Preclínical Research. PLOS Biol., vol. 13, no. 6, p. e1002165, Jun. 2015.
HACKAM, D. G.; REDELMEIER, D. A. Translation of Research Evidence From Animals to Humans. JAMA, vol. 296, no. 14, pp. 1727–1732, Oct. 2006.
BUTTERWORTH, K. T.; PRISE, K. M.; VERHAEGEN, F. Small animal image-guided radiotherapy: status, considerations and potential for translational impact. Br. J. Radiol., vol. 88, no. 1045, p. 20140634, Jan. 2015.
DESROSIERS, M.; DEWERD, L.; DEYE, J.; LINDSAY, P.; MURPHY, M. K.; MITCH, M.; MACCHIARINI, F.; STOJADINOVIC, S.; STONE, H. The Importance of Dosimetry Standardization in Radiobiology. J. Res. Natl. Inst. Stand. Technol., vol. 118, pp. 403–418, 2013.
GHITA, M.; MCMAHON, S. J.; THOMPSON, H. F.; MCGARRY, C. K.; KING, R.; OSMAN, O. S. O.; KANE, J. L.; TULK, A.; SCHETTINO, G.; BUTTERWORTH, K. T.; HOUNSELL, A. R.; PRISE, K. M. Small field dosimetry for the small animal radiotherapy research platform (SARRP), Radiat. Oncol., vol. 12, no. 1, pp. 1–10, 2017.
PEDERSEN, K. H.; KUNUGI, K. A.; HAMMER, C. G.; CULBERSON, W. S.; DEWERD, L. A. Radiation Biology Irradiator Dose Verification Survey, Radiat. Res., vol. 185, no. 2, pp. 163–168, 2016.
ICRU - International Commission on Radiation Units and Measurements. ICRU Report 91: Prescribing, Recording, and Reporting of Stereotactic Treatments with Small Photon Beams. J. Int. Comm. Radiat. Units Meas., vol. 14, no. 2, pp. 1–160, Jul. 2017.
BENEDICT, S. H.; SCHLESINGER, D. J.; GOETSCH, S. J. Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy, 2014. [Online] Available:http://www.hopkinsmedicine.org/radiation_oncology/treatments/stereotactic_radiosurgery_body_radiation_therapy.html. [Accessed: 14-Sep-2018].
ICRU-International Commission on Radiation Units and Measurements. ICRU Report 24: Determination of Absorbed Dose in a Patient Irradiated by Beams of X or Gamma Rays in Radiotherapy. J. Int. Comm. Radiat. Units Meas., vol. os13, no. 1, p. NP-NP, Sep. 1976.
ICRU-International Commission on Radiation Units and Measurements. ICRU Report 62: Prescribing, Recording and Reporting Photon Beam Therapy. J. Int. Comm. Radiat. Units Meas., vol. os32, no. 1, p. NP-NP, Nov. 1999.
NUNN, A. A.; DAVIS, S. D.; MICKA, J. A.; DEWERD, L. A. LiF:Mg,Ti TLD response as a function of photon energy for moderately filtered x-ray spectra in the range of 20-250 kVp relative to C60o. Med. Phys., vol. 35, no. 5, pp. 1859–1869, Apr. 2008.
DOS SANTOS, M.; PAGET, V.; BEN KACEM, M.; TROMPIER, F.; BENADJAOUD M. A.; FRANÇOIS A.; GUIPAUD O.; BENDERITTER M.; MILLIAT F. Importance of dosimetry protocol for cell irradiation on a low X-rays facility and consequences for the biological response. Int. J. Radiat. Biol., vol. 94, no. 6, pp. 597–606, Apr. 2018.
MASTERSON, M. E.; FEBO, R. Pretransfusion blood irradiation: Clínical rationale and dosimetric considerations. Med. Phys., vol. 19, no. 3, pp. 649–657, May 1992.
GRANTON, P.V.; PODESTA, M.; LANDRY, G.; NIJSTEN, S.; BOOTSMA, G.; VERHAEGEN, F. A combined dose calculation and verification method for a small animal precision irradiator based on onboard imaging. Med. Phys., vol. 39, no. 7Part1, pp. 4155–4166, Jun. 2012.
JEONG, J.; CHEN, Q.; FEBO, R.; YANG, J.; PHAM, H.; XIONG, J. P.; ZANZONICO, P. B.; DEASY, J. O.; HUMM, J. L.; MAGERAS, G. S. Adaptation, Commissioning, and Evaluation of a 3D Treatment Planning System for High-Resolution Small-Animal Irradiation. Technol. Cancer Res. Treat., vol. 15, no. 3, pp. 460–471, 2015.
MA, C.-M.; COFFEY, C. W.; DEWERD, L. A.; LIU, C.; NATH, R.; SELTZER, S. M.; SEUNTJENS J. P. AAPM TG61: Protocol for 40-300 kV x-ray beam dosimetry in radiotherapy and radiobiology. 2001.
ALMOND, P. R.; BIGGS, P. J.; HANSON, W. F. AAPM TG51: Protocol for Clínical Reference Dosimetry of High-Energy Photon and Electron Beams. Med. Phys., vol. 26, no. 1999, pp. 1–9, 1999.
IAEA- International Atomic Energy Agency. Technical Reports Series TRS 398: Absorbed Dose Determination in External Beam Radiotherapy. At. Energy Agency, pp. 1–229, 2000.
IAEA-International Atomic Energy Agency. Technical Reports Series TRS 483: Dosimetry of Small Static Fields Used in External Beam Radiotherapy An International Code of Practice for Reference and Relative Dose Determination. 1st ed. Viena: IAEA, 2017.
VERHAEGEN, F.; DUBOIS, L.; GIANOLINI, S.; HILL, M. A.; KARGER, C. P.; LAUBER, K.; PRISE, K. M.; SARRUT, D.; THORWARTH, D.; VANHOVE, C.; VOJNOVIC, B; WEERSINK, R.; WILKENS, J. J.; GEORG, D. ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges. Radiother. Oncol., vol. 126, no. 3, pp. 471–478, 2018.
LINDSAY, P. E.; GRANTON, P. V.; GASPARINI, A.; JELVEH, S.; CLARKSON, R.; VAN HOOF, S.; HERMANS, J.; KAAS, J.; WITTKAMPER, F.; SONKE, J.J.; VERHAEGEN, F.; JAFFRAY, D.A. Multi-institutional Dosimetric and geometric commissioning of image-guided small animal irradiators. Med. Phys., vol. 41, no. 3, 2014.
NIROOMAND-RAD A.; BLACKWELL C.R.; COURSEY B. M.; GALL K. P.; GALVIN J. M.; MCLAUGHLIN W. L.; MEIGOONI A.S.; NATH R.; RODGERS J.E.; SOARES C.G. Radiochromic Film Dosimetry. Am. Assoc. Phys. Med. AAPM No.63, vol. 25, no. 11, 1998.
TRYGGESTAD, E.; ARMOUR, M.; IORDACHITA, I.; VERHAEGEN, F.; WONG, J. W. A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform. Phys. Med. Biol., vol. 54, no. 17, pp. 5341–57, Sep. 2009.
WONG, J.; ARMOUR, E.; KAZANZIDES, P.; IORDACHITA, I.; TRYGGESTAD, E.; DENG, H.; MATINFAR, M; KENNEDY, C.; LIU, Z.; CHAN, T.; GRAY, O.; VERHAEGEN, F.; MCNUTT, T.; FORD, E.; DEWEESE, T. L. High-resolution, small animal radiation research platform with x-ray tomographic guidance capabilities. Int. J. Radiat. Oncol. Biol. Phys., vol. 71, no. 5, pp. 1591–9, Aug. 2008.
PIDIKITI, R.; STOJADINOVIC, S.; SPEISER, M.; SONG, H. K.; HAGER, F.; SOL-BERG, T. D. Dosimetric characterization of an image-guided stereotactic small animal irradiator. Phys. Med. Biol., vol. Volume 56, no. Number 8, pp. 2585–2599, 2011.
NEWTON, J.; OLDHAM, M.; THOMAS, A.; LI, Y.; ADAMOVICS, J.; KIRSCH, D. G.; DAS, S. Commissioning a small-field biological irradiator using point, 2D, and 3D dosimetry techniques. Med. Phys., vol. 38, no. 12, pp. 6754–62, Dec. 2011.
JOHNSTONE, C. D.; THERRIAULT-PROULX, F.; BEAULIEU, L.; BAZALOVA-CARTER, M. Characterization of a Plastic Scintillating Detector for the Small Animal Radiation Research Platform (SARRP). Med. Phys., pp. 394–404, 2018.
HILL, R.; HEALY, B.; HOLLOWAY, L.; KUNCIC, Z.; THWAITES, D.; BALDOCK, C. Advances in kilovoltage x-ray beam dosimetry. Phys. Med. Biol., vol. 59, no. 6, pp. 183–231, 2014.
DAMODAR J.; ODGERS D.; POPE D.; HILL R. A study on the suitability of the PTW microDiamond detector for kilovoltage x-ray beam dosimetry. Appl. Radiat. Isot., vol. 135, pp. 104–109, 2018.
NA Y. H.; WANG Y.-F. ; BLACK P. J.; VELTEN C.; QIAN X. ; LIN S.-C. ; ADAMOVICS J.; WUU C.-S. Dosimetric and geometric characteristics of a small animal image-guided irradiator using 3D dosimetry/optical CT scanner. Med. Phys., vol. 45, no. 7, pp. 3330–3339, Jul. 2018.
LOW D. A.; HARMS W. B.; MUTIC S.; PURDY J. A. A technique for the quantitative evaluation of dose distributions. Med. Phys., vol. 25, no. 5, pp. 656–661, May 1998.
BUTSON M. J.; CHEUNG T.; YU P. K. N. Radiochromic film dosimetry in water phantoms. Phys. Med. Biol., vol. 46, no. 1, pp. N27–N31, Jan. 2001.
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