Issues on the Electron Stopping Power Modulated by Magnetic and Electric Fields
DOI:
https://doi.org/10.15392/bjrs.v9i1A.1458Keywords:
Electrons, Electromagnetic, Fields, TTFAbstract
Ionizing radiation has been employed in conjunction with various clinical modalities for therapeutic purposes. Often, surgery, chemo and radiation therapies have been combined on the arsenal against cancer. Nontraditional techniques, as Tumor Treating Fields (TTF) that uses low-intensity variable electric fields, have also been employed for the treatment of brain tumors, glioblastoma multiforme (GBM), with promising results in reducing the harmful radio and chemotherapy effects, while maintaining the same tumor control rates. The combination of electromagnetic field and chemotherapy has already held a clinical investigation; however, it is missing the experimental and theoretical studies coupling electric and magnetic fields with electron radiotherapy. Herein, a theoretical analysis involving the Stopping Power of electron particles in conjunction with static electric and magnetic fields (E, H) was addressed in order to study the relevance of the use of external electromagnetic fields in radiotherapy. The findings reinforce the possibility of application of the coupling magnetic field with electron radiotherapy, and open a horizon to future experimental and clinical studies if the relevance is enough.
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References
What is the cancer? Available at: https://www.inca.gov.br/o-que-e-cancer. Last accessed 10 Jun. 2019;
Glioblastoma Multiforme. Available at: https://www.hospitalinfantilsabara.org.br/sintomas-doencas-tratamentos/glioblastoma-multiforme/. Last accessed 10 Jun. 2019;
H. GOLLA, M. AHMAD, M. GALUSHKO, J. HAMPL. Glioblastoma multiforme from diagnosis to death: a prospective, hospital-based, cohort, pilot feasibility study of patient reported symptoms and needs. Support Care Cancer, v. 22, p. 3341-3352, 2014;
R. STUPP MD, S. TAILLIBERT MD, A. KANNER MD, S. KESARI. Maintenance Therapy with Tumor-Treating Fields plus Temozolomide vs. Temozolomide Alone for Glioblastoma - A Randomized Clinical Trial. JAMA, v. 314, p. 2535-2543, 2015;
G. SHENOUD; L. SOUHAMI; K. PETRECCA et al. A phase 2 trial of Neoadjuvant Temozolomide followed by Hypofractionated Accelerated Radiation Therapy with Concurrent and Adjuvant Temozolomide for Patients with Glioblastoma. International Journal of Radiation Oncology, Biology, Physics, v. 97, p. 487- 494, 2017;
D. FABIAN; M. P. G. P. EIBL; I. ALNAHHAS et al. Treatment of Glioblastoma (GBM) with the Addition of Tumor Treating Fields (TTF): A Review. Cancers, v. 11(2), p. 174-186, 2019;
W. W. ALBUQUERQUE, R. M. COSTA, T. S. FERNANDES, A. L. Porto. Evidences of the static magnetic field influence on cellular systems. Progress in Biophysics and Molecular Biology, v. 121, p. 16-28, 2016;
F. S. BARNES, B. GREENBAUM. The Effects of Weak Magnetic Fields on Radical Pairs. Bioelectromagnetics, v. 36, p.45-54, 2015;
D. WANG, Z. WANG, L. ZHANG, Z. LI. Cellular ATP Levels are Affected by Moderate and Strong Static Magnetic Fields. Bioelectromagnetics, v. 39, p. 352-360, 2018;
A. R. JONES. Magnetic field effects in proteins. Molecular Physics, v. 114, p. 1691-1702, 2016;
A. WASAK, R. DROZD, D. JANKOWIAK, R. RAKOCZY. Rotating magnetic field as tool for enhancing enzymes properties - laccase case study. Scientific Reports, v. 9, p. 3707-3716, 2019;
I. KHODARAHMI, H. MOBASHERI, MASOUMEH FIROUZI. The effect of 2.1 T static magnetic field on astrocyte viability and morphology. Magnetic Resonance Imaging, v. 28, p. 903-909, 2010;
Radiobiology Basics – RBE, OER, LET. Available at: https://indico.cern.ch/event/205479/contributions/399005/attachments/313322/437341/Radiobiology.pdf. Last accessed 01 Sep. 2020;
D. J. GRIFFITHS. Introduction to Electrodynamics, 4th ed. São Paulo: Pearson, 2013;
Particle Interactions in Particle Detectors – CERN Indico. Available at: https://indico.cern.ch/event/294651/contributions/671929/attachments/552041/760669/Delmastro_ESIPAP2014_3.pdf. Last accessed 10 Jun. 2019;
Passage of particles through matter – PDG. Available at: http://pdg.lbl.gov/2009/reviews/rpp2009-rev-passage-particles-matter.pdf Last accessed 10 Jun. 2019.
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