Development of a shielding device for radiotherapy of breast cancer-bearing mice
DOI:
https://doi.org/10.15392/bjrs.v8i1A.1164Keywords:
ionizing radiation, lead, thermoluminescent dosimetersAbstract
Breast cancer is the fifth most common cause of death worldwide. Currently, one of the standard treatments for breast cancer is radiation therapy (RT). On the other hand, mouse models have been used in pre-clinical studies for breast cancer RT, requiring dedicated shielding to exposure the breast region. In this work, we considered the values of the lead attenuation coefficient and the tenth reducing layer for a 60Co irradiator and developed a lead shielding device for breast cancer-bearing mice to be exposed to localized breast RT. Five-kg of lead were exposed to temperature of 340ºC and inserted into an aluminum mold previously adjusted to the dimensions of the device. After solidification, the device was shaped into a cylinder with dimension of 14 x 15 x 7 cm (height x width x thickness, respectively). A round cut-out for breast exposure of 1 cm in diameter was made at 5 cm from the basis of the device. For shielding device validation, we performed calibrations to establish a dose of 10 Gy in the target. Fifteen CaSO4:Dy thermoluminescent dosimeters were distributed along a 50 mL conical tube to simulate the mouse position inside the shielding. The shielding device was placed at a fixed distance of 10 cm from the target for optimal exposure time. After irradiation, the dosimeters were read on a thermoluminescent reader. According to our results, we were able to develop a body-shielding device that assured the required dose for RT of breast cancer in mice.
- Views: 136
- PDF Downloads: 145
Downloads
References
WHO- World Health Organization. Cancer. Available at <https://www.who.int/news-room/fact-sheets/detail/cancer >. Last accessed : 26.Jul. 2019.
AKRAM, M.; IQBAL, M.; DANIYAL, M. et al. Awareness and current knowledge of breast cancer. Biol Res, v. 50, n. 1, p. 33, 2017.
KRUG, D.; BAUMANN, R.; BUDACH, W. et al. Current controversies in radiotherapy for breast cancer. Radiat Oncol, v. 12, n. 1, p. 25, 2017.
MANNING, H. C.; BUCK, J. R.; COOK, R. S. Mouse models of breast cancer: platforms for discovering precision imaging diagnostics and future cancer medicine. J Nucl Med, v. 57, n. Suppl 1, p. 60S-8S, 2016.
GIESE, A. P.; GUARNASCHELLI, J. G.; WARD, J. A. et al. Radioprotective effect of aminothiol PrC-210 on irradiated inner ear of guinea pig. PLoS One, v. 10, n. 11, p. e0143606, 2015.
MIBIORESEARCH. Utilization of radiation in the preclinical oncology setting - MI Bioresearch. Disponível em: < https://www.mibioresearch.com/knowledge-center/utilization-radiation-preclinical-oncology-setting/>. Last accessed : 12 Sept. 2019.
OLIVEIRA, M. L. D.; MAIA, A. F.; NASCIMENTO, N. C. E. S. et al. Influence of thermoluminescent dosimeters energy dependence on the measurement of entrance skin dose in radiographic procedures. Radiol Bras, v. 43, n. 2, p. 5, 2019.
MCALISTER, D. R. Gamma ray attenuation properties of common shielding materials. Available at <https://www.eichrom.com/wp-content/uploads/2018/02/Gamma-Ray-Attenuation-White-Paper-by-D-M-rev-6-1-002.pdf>. Last accessed : 12 Sept. 2019.
PORTAL, G. Review of the principal materials available for thermoluminescent dosimetry. Radiat Prot Dosimetry, v. 17, n. 1-4, p. 351-357, 1986.
LAKSHMANAN, A. Development and application of solid forms of CaSO4:Dy thermoluminescent dosemeters in radiation protection dosimetry-A review. Radiat Prot Dosimetry, v. 181, n. 2, p. 57-99, 2018.
CAMPOS, L. L.; LIMA, M. F. Dosimetric properties of CaSO4:Dy teflon pellets produced at IPEN. Radiat Prot Dosimetry, v. 14, n. 4, p. 333-335, 1986.
HUBBELL, J. H. Photon mass attenuation and mass energy-absorption coefficients for H, C, N, O, Ar, and seven mixtures from 0.1 KeV to 20 MeV. Radiat Res, v. 70, n. 1, p. 58-81, 1977.
SOHN, J. W.; MACKLIS, R.; SUH, J. K. et al. A mobile shield to reduce scatter radiation to the contralateral breast during radiotherapy for breast cancer: preclinical results. Int J Radiat Oncol Biol Phys, v. 43, n. 5, p. 1037-41, 1999.
GRASSO, C.; FABRE, M. S.; COLLIS, S. V. et al. Pharmacological doses of daily ascorbate protect tumors from radiation damage after a single dose of radiation in an intracranial mouse glioma model. Front Oncol, v. 4, p. 356, 2014.
KAPLON, R.; HADZIAHMETOVIC, M.; SOMMERFELD, J. et al. The application of radiation therapy to the Pediatric Preclinical Testing Program (PPTP): results of a pilot study in rhabdomyosarcoma. Pediatr Blood Cancer, v. 60, n. 3, p. 377-382, 2013.
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2020 Brazilian Journal of Radiation Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing: The BJRS articles are licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
