A feasibility study for a new one-day protocol for [99mTc]TcDTPA2- and [99mTc]TcDMSA2- renal scintigraphy on dilated and non-dilated pediatric patients: underlying rationale

Authors

DOI:

https://doi.org/10.15392/2319-0612.2023.2158

Keywords:

Radionuclide Imaging, Pediatric Nephrology, Renal cortical scintigraphy

Abstract

PurposeThis work aimed at evaluating the possibility of performing renal exams of dynamic renal (DRS) and static renal (SRS) scintigraphy on the same day (one-day protocol, ODP), exams that are currently performed in two days. Approach. 25 infants (50 kidneys) of both genders, aged 8.4 ± 5.9 years, underwent an F+20 DRS protocol with [99mTc]TcDTPA2- followed by [99mTc]TcDMSA2- administration for the performance of SRS images at 3, 6 and 24 h. Dynamic images (DRS) were classified as dilated (D), undetermined (U), and non-dilated (P). Static images (SRS) were classified as: depressed in accented degree (DA); depressed in moderate degree (DM); depressed in mild degree (DL) and normal (NL). Results. Out of the 25 patients (50 kidneys), 7 (14 kidneys) were excluded by functional exclusion, hence 18 patients (36 kidneys) were clinically compared regarding their static images after 3, 6 and 24 h, resulting in 33.0% of dilated and 66.7% non-dilated. Only two patients of the dilated group were classified as obstructed. At the group with non-dilated and dilated but non-obstructed kidneys, 100% of them had the same clinical classification at 6 and 24 h images. Conclusions. Performance of both DRS and SRS exams in a single day for pediatric patients, when medical requests are carried out jointly, is feasible in a population with or without dilatation, when the difference between dynamic and static images is of at least 6 h. Due to the small number of obstructed kidneys in this study, further evaluation in this population is needed.

Downloads

Download data is not yet available.

Author Biography

Victor M. Balcão, University of SorocabaPhageLab - Laboratory of Biofilms and BacteriophagesCidade Universitária Prof. Aldo VannucchiRodovia Raposo Tavares, km 92.5CEP 18023-000 Sorocaba/SPBrazil

PhageLab - Laboratory of Biofilms and Bacteriophages

References

LEE, R.S.; CENDRON, M.; KINNAMON, D.D.; NGUYEN, H.T. Antenatal hydronephrosis as a predictor of postnatal outcome: a meta-analysis. Pediatrics, v. 118, p. 586-593, 2006. DOI: https://doi.org/10.1542/peds.2006-0120

ZANZONICO, P. Principles of nuclear medicine imaging: planar, SPECT, PET, multi-modality, and autoradiography systems. Radiat Res, v. 177, p. 349-364, 2012. DOI: https://doi.org/10.1667/RR2577.1

KHARFI, F. Principles and Applications of Nuclear Medical Imaging: A Survey on Recent Developments. In: KHARFI, F. Imaging Radioanal Tech Interdiscip Res - Fundam Cut Edge Appl [Internet], London: IntechOpen; Available from: https://www.intechopen.com/chapters/43519, 2013. DOI: https://doi.org/10.5772/54884

ARCHER, K.D.; BOLUS, N.E. Survey on the Use of Nuclear Renal Imaging in the United States. J Nucl Med Technol, v. 44, p. 223-226, 2016. DOI: https://doi.org/10.2967/jnmt.116.181339

DURAND, E.; PRIGENT, A. The basics of renal imaging and function studies. Q J Nucl Med, v. 46, p. 249-267, 2002.

HAUSER, W.; ATKINS. H.L.; NELSON, K.G.; RICHARDS, P. Technetium-99m DTPA: a new radiopharmaceutical for brain and kidney scanning. Radiology, v. 94, p. 679-684, 1970. DOI: https://doi.org/10.1148/94.3.679

LIN, C.C.; SHIH, B.F.; SHIH, S.L.; TSAI, J.D. Potential Role of Tc-99m DTPA Diuretic Renal Scan in the Diagnosis of Calyceal Diverticulum in Children. Medicine (Baltimore), v. 94, p. e985, 2015. DOI: https://doi.org/10.1097/MD.0000000000000985

PIEPSZ, A.; COLARINHA, P.; GORDON, I.; HAHN, K.; OLIVIER, P.; ROCA, I.; SIXT, R.; VAN VELZEN, J.; Guidelines on 99mTc-DMSA scintigraphy in children. Eur J Nucl Med [Internet], v. 28, p. BP37-BP41, 2001.

GORDON, I.; PIEPSZ, A.; SIXT, R. Auspices of Paediatric Committee of European Association of Nuclear Medicine. Guidelines for standard and diuretic renogram in children. Eur J Nucl Med Mol Imaging, v. 38, p. 1175-1188, 2011. DOI: https://doi.org/10.1007/s00259-011-1811-3

ARNOLD, R.W.; SUBRAMANIAN, G.; MCAFEE, J.G.; BLAIR, R.J.; THOMAS, F.D. Comparison of 99mTc complexes for renal imaging. J Nucl Med, v. 16, p. 357-367, 1975.

KANE, S.M.; DAVIS, D.D. Technetium-99m. [Updated 2022 Sep 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559013/, 2022.

HUANG, S.H.; ELIASZIW, M.; SPENCE, J.D.; FILLER, G.; VEZINA, W.C.; CHURCHILL, D.N.; CATTRAN, D.C.; RICHARDSON, B.; HOUSE, A.A. The (99m)Tc-DTPA urinary clearance method may be preferable to the plasma disappearance method for assessing glomerular filtration rate in diabetic nephropathy. Nephron Clin Pract, v. 128, p. 367-372, 2014. DOI: https://doi.org/10.1159/000368901

COMET, M.; VIDAL, M. Radiopharmaceutiques: chimie des radiotraceurs et applications biologiques. Grenoble: Presses Universitaires de Grenoble; 1998.

LEE, K.W.; BIN, K.T.; JEONG, M.S.; SHONG, M.H.; SHIN, Y.T.; RO, H.K. Tc-99m dimercaptosuccinic acid(DMSA) renal scintigraphy in patients with acute pyelonephritis. Korean J Intern Med, v. 10, p. 43-47, 1995. DOI: https://doi.org/10.3904/kjim.1995.10.1.43

WANG, Y.; LI, M.; DAI, S.; LI, Y. The Role of Tc-99m DTPA Renal Dynamic Scintigraphy in Retroperitoneal Liposarcoma. Biomed Res Int, v. 2020, p. 9765162, 2020. DOI: https://doi.org/10.1155/2020/9765162

DEMIR, F.; DEMIR, M. Comparison of 99mTc-DMSA, 99mTc-DTPA and 99mTc-MAG3 Renal Scintigraphy in the Calculation of Relative Renal Function. J Urol Surg, v. 7, p. 130-133, 2020. DOI: https://doi.org/10.4274/jus.galenos.2019.3107

ONEN, A. Grading of Hydronephrosis: An Ongoing Challenge. Front Pediatr, v. 8, p. 458, 2020. DOI: https://doi.org/10.3389/fped.2020.00458

DJEKIDEL, M.; GOVINDARAJAN, K.K. Nuclear Medicine Pediatric Assessment, Protocols, And Interpretation [Internet]. StatPearls [Internet], Available from: https://www.ncbi.nlm.nih.gov/books/NBK572132/, 2022.

ALSABEA, H. Types of Renal Scintigraphy. J Nucl Med Radiat Ther, v. 8, p. 347, 2017. DOI: https://doi.org/10.4172/2155-9619.1000347

DE MAN, K.E.; TROCH, M.E.; DOBBELEIR, A.A.; DUONG, H.P.; GOETHALS, I.M. Comparison of the EANM and SNM guidelines on diuretic renography in children. Nucl Med Commun, v. 36, p. 486-448, 2015. DOI: https://doi.org/10.1097/MNM.0000000000000278

CHURCH, J.T.; JARBOE, M.D. Vascular Access in the Pediatric Population. Surg Clin North Am, v. 97, p. 113-128, 2017. DOI: https://doi.org/10.1016/j.suc.2016.08.007

DOMINGUES, F.C.; FUJIKAWA, G.Y.; DECKER, H.; ALONSO, G.; PEREIRA, J.C.; DUARTE, P.S. Comparison of Relative Renal Function Measured with Either 99mTc-DTPA or 99mTc-EC Dynamic Scintigraphies with that Measured with 99mTc-DMSA Static Scintigraphy. Int Braz J Urol, v. 32, p. 405-409, 2006. DOI: https://doi.org/10.1590/S1677-55382006000400004

RAMBALDI, P.F.; ZUCCHETTA, P. Nuclear Medicine in Pediatric Nephro-urology. In: MANSI, L.; LOPCI, E.; CUCCURULLO, V.; CHITI, A. Clinical Nuclear Medicine in Pediatrics. Springer, Cham.; 2016. DOI: https://doi.org/10.1007/978-3-319-21371-2_10

SFAKIANAKIS, G.N.; SFAKIANAKI, E.D. Nuclear medicine in pediatric urology and nephrology. J Nucl Med, v. 29, p. 1287-1300, 1988.

FELD, L.G.; MATTOO, T.K. Urinary Tract Infections and Vesicoureteral Reflux in Infants and Children. Pediatr Rev, v. 31, p. 451-463, 2010. DOI: https://doi.org/10.1542/pir.31.11.451

BIASSONI, L. Pitfalls and Limitations of Radionuclide Renal Imaging in Pediatrics. Semin Nucl Med, v. 45, p. 411-427, 2015. DOI: https://doi.org/10.1053/j.semnuclmed.2015.04.001

MORENO, E.A.C.; CARVALHO, A.A.S.; PAZ, E.P.A. Pain in child undergoing venipuncture: effects of an anesthetic cream. Esc Anna Nery, v. 18, p. 392-399, 2014. DOI: https://doi.org/10.5935/1414-8145.20140056

SEBASTIANO, B.; SERENA, P.; LUANA, P. Nuclear medicine in the pediatric field. Journal of Advanced Health Care, v. 3, p. 36-65, 2021. DOI: https://doi.org/10.36017/JAHC2105-006

JANG, S.J. Nuclear Medicine in Pediatric Urology. Child Kidney Dis - Korean Soc Pediatr Nephrol, v. 19, p. 14-22, 2015. DOI: https://doi.org/10.3339/chikd.2015.19.1.14

ABDUL-HAK, C.K.; BARROS, Â.F. The incidence of phlebitis in a Medical Clinical Unit. Texto Context - Enferm, v. 23, p. 1-6, 2014. DOI: https://doi.org/10.1590/0104-07072014000900013

CNS - Brazilian National Health Council. Resolution no 466, of December 12th, 2012, CNS - Brazilian National Health Council, 2012.

ANVISA - Agência Nacional de Vigilância Sanitária. Resolução de Diretoria Colegiada (RDC) no 38, de 4 de Junho de 2008. Anvisa, Brasília DF; 2008.

IPEN - Instituto de Pesquisas Energéticas e Nucleares. Gerador IPEN-TEC pertecnetato de sódio (99m Tc) [Internet]. IPEN - Inst Pesqui Energéticas Nucl, Available from: https://www.ipen.br/portal_por/portal/produtos.php?secao_id=35, 2022.

MURUGAPOOPATHY, V.; GUPTA, I.R. A primer on congenital anomalies of the kidneys and urinary tracts (CAKUT). Clin J Am Soc Nephrol, v. 15, p. 723-731, 2020. DOI: https://doi.org/10.2215/CJN.12581019

ONO, C.R.; SAPIENZA, M.T.; MACHADO, B.M.; PAHL, M.M.C.; LIBERATO JR, W.P.; OKAMOTO, M.R.Y.; GARCEZ, A.T.; WATANABE, T.; COSTA, P.L.A.; BUCHPIGUEL, C.A. Standardization of a method to calculate absolute renal uptake of 99mTc-DMSA in children. Radiol Bras, v. 39, p. 33-38, 2006. DOI: https://doi.org/10.1590/S0100-39842006000100008

MORRIS, S.C.; CHITTENDEN, S.J.; RIVENS, I.; HEARY, T.A.; VANSTONE, C.; MELLER, S.T. Absolute 99Tcm-DMSA renal uptake in children: a study of 321 kidneys. Nucl Med Commun, v. 16, p. 566-571, 1995. DOI: https://doi.org/10.1097/00006231-199507000-00007

MOORIN, R. 99mTc-DMSA absolute uptake: normal pediatric values at 2-4 hours. J Nucl Med Technol, v. 29, p. 22-29, 2001.

MAJD, M.; BAR-SEVER, Z.; SANTOS, A.I.; DE PALMA, D. The SNMMI and EANM Procedural Guidelines for Diuresis Renography in Infants and Children. J Nucl Med, v. 59, p. 1636-1640, 2018. DOI: https://doi.org/10.2967/jnumed.118.215921

VALI, R.; ARMSTRONG, I.S.; BAR-SEVER, Z.; BIASSONI, L.; BORGWARDT, L.; BROWN, J.; GRANT, F.D.; MANDELL, G.A.; MAJD, M.; NADEL, H.R.; NG, T.S.C.; ROCA-BIELSA, I.; ROHRINGER, T.J.; SANTOS, A.I.; SEGHERS, V.; SHAIKH, N.; TREVES, S.T.; ZAFFINO-NEVROTSKI, T.; ZUCCHETTA, P.; LIM, R. SNMMI procedure standard/EANM practice guideline on pediatric [99mTc]Tc-DMSA renal cortical scintigraphy: an update. Clin Transl Imaging, v. 10, p. 173-184, 2022. DOI: https://doi.org/10.1007/s40336-022-00484-x

WEYER, K.; NIELSEN, R.; PETERSEN, S.V.; CHRISTENSEN, E.I.; REHLING, M.; BIRN, H. Renal uptake of 99mTc-dimercaptosuccinic acid is dependent on normal proximal tubule receptor-mediated endocytosis. J Nucl Med, v. 54, p. 159-165, 2013. DOI: https://doi.org/10.2967/jnumed.112.110528

GOUNDEN, V.; BHATT, H.; JIALAL, I. Renal Function Tests [Internet]. StatPearls [Internet], Available from: https://www.ncbi.nlm.nih.gov/books/NBK507821/, 2021.

LOWENSTEIN, J.; GRANTHAM, J.J. The rebirth of interest in renal tubular function. Am J Physiol Renal Physiol, v. 310, p. F1351-F1355, 2016. DOI: https://doi.org/10.1152/ajprenal.00055.2016

VERBOVEN, M.; HAM, H.R.; JOSEPHSON, S.; COLLIER, F.; HALL, M.; PIEPSZ, A. 99Tcm-DMSA uptake in obstructed kidneys. How inaccurate are the 5 h measurements? Nucl Med Commun, v. 8, p. 45-48, 1987. DOI: https://doi.org/10.1097/00006231-198701000-00007

ZANANIRI, M.C.; JARRITT, P.H.; SARFARAZI, M.; ELL, P.J. Relative and absolute 99Tcm-DMSA uptake measurements in normal and obstructed kidneys. Nucl Med Commun, v. 8, p. 869-880, 1987. DOI: https://doi.org/10.1097/00006231-198711000-00004

PAUWELS, E.K.; LYCKLAMA À NIJEHOLT, A.A.; ARNDT, J.W.; JONAS, U. The determination of relative kidney function in obstructive uropathy with 99Tcm-DMSA. Nucl Med Commun, v. 8, p. 865-867, 1987. DOI: https://doi.org/10.1097/00006231-198711000-00003

HOLNESS, J.; FLEMING, J.; WARWICK, J. Measuring GFR Using the Plasma Clearance of 99mTc-DTPA. Am J Kidney Dis, v. 65, p. 806-809, 2015. DOI: https://doi.org/10.1053/j.ajkd.2015.02.333

VADIVELU, K.; HILLER, J.; BRANNON, D.; REHMAN, B. Common pediatric nuclear medicine imaging studies: a comprehensive review, J Nucl Med, v. 63, p. 2664, 2022.

AGRICOLA, E.; MARINI, C.; STELLA, S.; MONELLO, A.; FISICARO, A.; TUFARO, V.; SLAVICH, M.; OPPIZZI, M.; CASTIGLIONI, A.; CAPPELLETTI, A.; MARGONATO, A. Effects of functional tricuspid regurgitation on renal function and long-term prognosis in patients with heart failure. J Cardiovasc Med (Hagerstown), v. 18, p. 60-68, 2017. DOI: https://doi.org/10.2459/JCM.0000000000000312

CHARYTAN, D.; KUNTZ, R.E. The exclusion of patients with chronic kidney disease from clinical trials in coronary artery disease. Kidney Int, v. 70, p. 2021-2030, 2006. DOI: https://doi.org/10.1038/sj.ki.5001934

DE NEGRI, D.C.; AVELAR, A.F.M.; ANDREONI, S.; PEDREIRA, M.L.G. Predisposing factors for peripheral intravenous puncture failure in children. Rev Lat Am Enfermagem, v. 20, p. 1072-1080, 2012. DOI: https://doi.org/10.1590/S0104-11692012000600009

ROGASCH, J.M.M.; BAMM, M.; BÄDER, M.; JAESCHKE, E.; BRENNER, W.; VAN DER GIET, M.; AMTHAUER, H.; SCHATKA, I. Comparison of glomerular filtration rate (GFR) with Tc-99m-DTPA and tubular extraction rate (TER) with Tc-99m-MAG3 in potential living kidney donors: Feasibility of a one-day protocol. Nuklearmedizin, v. 58, p. 460-469, 2019. DOI: https://doi.org/10.1055/a-1015-0096

Downloads

Published

2023-03-14

How to Cite

Trevisan, F., Nascimento, B., Chibana, G., Maeda, L., Vila, M., Yoshida, V., Aranha, N., Balcão, V. M., & Oliveira Júnior, J. M. (2023). A feasibility study for a new one-day protocol for [99mTc]TcDTPA2- and [99mTc]TcDMSA2- renal scintigraphy on dilated and non-dilated pediatric patients: underlying rationale. Brazilian Journal of Radiation Sciences, 11(01). https://doi.org/10.15392/2319-0612.2023.2158

Issue

Section

Articles

Most read articles by the same author(s)