Quality control in blood irradiation

F. Lopes; R.C.G. Rocha; E. Munhoz; F.C.  Trigo; V.B.E.R. Feijó; M. Fernandes; T.C. De Paula; L.G. Padilha Filho; G.S. Araujo

doi:10.15392/2319-0612.2023.2183

Authors

F. Lopes Universidade Estadual de Londrina
R.C.G. Rocha Hemocentro - Hospital Universitário. Universidade Estadual de Londrina
E. Munhoz Hemocentro - Hospital Universitário. Universidade Estadual de Londrina
F.C. Trigo Hemocentro - Hospital Universitário. Universidade Estadual de Londrina
V.B.E.R. Feijó Hemocentro - Hospital Universitário. Universidade Estadual de Londrina
M. Fernandes Hemocentro - Hospital Universitário. Universidade Estadual de Londrina
De Paula T.C METROBRAS – Metrologia das Radiações Ionizantes
L.G. Padilha Filho Fundação Técnico Educacional Souza Marques.
G.S. Araujo Fundação Técnico Educacional Souza Marques

DOI:

https://doi.org/10.15392/2319-0612.2023.2183

Keywords:

Quality Control, calibration processes, radiation dose rate.

Abstract

Irradiation is a technique used in hemotherapy to functionally inactivateviable lymphocytes, in cellular blood components, to reduce the risk of Transfusion-associated Graft-versus-Host Disease (AT-GVHD), is rare but letal. One way to avoid it is to irradiate blood componentes in situations such as: intrauterine transfusion, newborns, patients receiving immunosuppressive therapy in bone marrow transplantation. Thus, it is extremely important that blood component is irradiated and, above all, ensure that the minimum dose is 25 Gy.The blood policy in Brazil is implemented through laws and normative decrees, giving rise to a legal system that underpins the actions of hemotherapy services. In order to correct verify absorbed doses and the quality assurance process as well as the safety for the irradiator operators we describe in this paper a several of physical measurements that is mandatory to support a physicist to evaluate the quality assurance during and after the irradiation process. The results obtained from this physical measurements provided a guarantee of proper radiation dose used in hemotherapy as well as methods and procedures applied to protect the patient, employees and general public due to procedure of blood irradiation accordling the Technical Regulation of Hemotherapy Procedures of the National Health Surveillance Agency (ANVISA) and safety regulations by National Nuclear Energy Commission (CNEN).

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