The image reconstruction influence in relative measurement in SPECT / PET / CT animal

Sarah Soriano; Thiago Barboza; Sérgio Augusto Lopes Souza; Lidia Vasconcellos de Sá

doi:10.15392/bjrs.v6i1.305

The image reconstruction influence in relative measurement in SPECT / PET / CT animal

Authors

Sarah Soriano Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission
Thiago Barboza Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro
Sérgio Augusto Lopes Souza Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro
Lidia Vasconcellos de Sá Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission

DOI:

https://doi.org/10.15392/bjrs.v6i1.305

Keywords:

SPECT/PET/CT animal, reconstruction, preclinical study

Abstract

The objective of this study was to evaluate spatial resolution and the influence of different reconstruction methods in a FLEX Triumph ™ Pre-Clinical Imaging System images applied to mice C57BL6 dosimetry in a new radiopharmaceuticals development for humans use. CT and SPECT images were obtained from a homemade phantom containing four spheres with diameters (d) simulating iodine-accumulating injuries at University Hospital (HU / UFRJ). The SPECT images were reconstructed with filtered back projection method (FBP) and the influence in resolution and partial volume effect was evaluated for different filters: Hamming, Hann and Ramp. The resolution found was 9.3 to 9.4 mm, significantly lower than the value provided by the manufacturer, 1.6 mm. Thus, the protocol for mice can be optimized by FBP reconstruction method and Hamming filter, 0.5 cut-off, yielding a resolution from 9.3 to 9.4 mm. This value indicates that iodine-accumulating regions diameter below 9.3 mm is not quantifiable.

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Author Biographies

Sarah Soriano, Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission

Pos Graduation student, Medical Physics Department

Thiago Barboza, Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro

Pos Graduation student, Radiology Department

Sérgio Augusto Lopes Souza, Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro

Radiology Department

Lidia Vasconcellos de Sá, Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission

Medical Physics Department

References

MARTIC- KEHL, I. MSCHIBLI, R., SCHUBIGER, A. P. Can animal data predict human outocme? Problems and pitfalls of translational animal research. Eur J Med Mol Imaging,v. 39, p. 1492-1496, 2012.

MEIKLE R S, KENCH P, KASSIOU M, BANATI BR. Small animal SPECT and its place in the matrix of molecular imaging technologies. Phys Med Biol, v. 50, p. R45-R61, 2005.

POWSNER R. A, POWSNER E. R. Essential Nuclear Medicine Physics, Blackwell Publisher, Boston & United States of American, 2006.

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Published

2018-01-28

How to Cite

Soriano, S., Barboza, T., Souza, S. A. L., & Sá, L. V. de. (2018). The image reconstruction influence in relative measurement in SPECT / PET / CT animal. Brazilian Journal of Radiation Sciences, 6(1). https://doi.org/10.15392/bjrs.v6i1.305

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Issue

Vol. 6 No. 1 (2018)

Section

Articles

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