Impact of the counts density of calibration image and the image reconstruction parameters in 131I SPECT image quantification

Samira Marques Carvalho; Ana Paula Marques Costa; Celso Dario Ramos; Sérgio Querino Brunetto; Daniel Alexandre Baptista Bonifácio

doi:10.15392/bjrs.v6i1.332

Authors

Samira Marques Carvalho Comissão Nacional de Energia Nuclear
Ana Paula Marques Costa Serviço de Medicina Nuclear, SMN/HC-UNICAMP
Celso Dario Ramos Serviço de Medicina Nuclear, SMN/HC-UNICAMP
Sérgio Querino Brunetto Centro de Engenharia Biomédica, CEB/UNICAMP
Daniel Alexandre Baptista Bonifácio Instituto de Radioproteção e Dosimetria, IRD/CNEN

DOI:

https://doi.org/10.15392/bjrs.v6i1.332

Keywords:

SPECT, calibration, uncertainties, quantification accuracy.

Abstract

Iodine-131 (¹³¹I) has been used for diagnosis and therapy in Nuclear Medicine Centers in Brazil for more than 50 years. The present study aims to investigate the impact of the counts density and the reconstruction parameters in the calibration factor determination and in the image quantification, considering the reality of Brazilian dosimetry studies. For this task, images were quantified using calibration images with high and low counts density and reconstructed adopting two different parameters approaches, usually employed in patients images. SPECT quantification results presented in this work follow other previous ¹³¹I SPECT studies and suggest that, due to the long time interval between the first e last image, as required by the Brazilian guideline, the image quantification accuracy can be improved if the counts density in calibration measurements is considered.

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