Dosimetric effectiveness in implants with distinct ho166-seed distributions in a prostate model

Viviane Vitória Bento Braga; Tarcísio Passos Ribeiro de Campos

doi:10.15392/bjrs.v7i2A.603

Authors

Viviane Vitória Bento Braga Federal University of Minas Gerais
Tarcísio Passos Ribeiro de Campos Federal University of Minas Gerais

DOI:

https://doi.org/10.15392/bjrs.v7i2A.603

Keywords:

prostate cancer, brachytherapy, Ho-166 seeds.

Abstract

Currently, there is a need to produce new therapeutic techniques for the treatment of prostate tumors, considering the high incidence of the disease and significant morbidity rates associated with surgery and radiotherapy. Simulations in brachytherapy produce essential information about the efficiency and dosimetric efficacy compared to other techniques. This study estimated the efficiency of dosimetry by parameters of merit generated from volumetric distributions of absorbed doses simulating two spatial distributions of Ho-166 seeds in a prostate model. A computer voxel model was developed, using the SISCODES (Computational System for Dosimetry by Neutrons and Photons by Stochastic Methods applied to radiology and radiotherapy) code. The virtual model reproduced a cubic box, filled with muscle equivalent tissue (TE), in which a 5-cm diameter sphere with TE-prostate was positioned 2-cm from the air-interface. Two Ho-166 seed distributions were employed with distinct pitches: 9 and 10 mm, with same distance between seed of 8mm in a fillet (needle). The MCNP5 code generated the energy deposited per unit mass in each voxel .The spatial dose distributions were obtained for each of the seed distributions. The following parameters-of-merit were evaluated: maximum dose values and histograms. The parameters were compared between the two simulated groups. It was possible to evaluate the most appropriate distribution to the prostate brachytherapy, which has been shown to be a function of the injected seed activity.

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Author Biographies

Viviane Vitória Bento Braga, Federal University of Minas Gerais

Department of Nuclear Engineering

Concentration Area: Radiation Sciences
Research Line: Applications of Radiation to Biomedical

Tarcísio Passos Ribeiro de Campos, Federal University of Minas Gerais

Department of Nuclear Engineering

Concentration Area: Radiation Sciences

References

PODGORSAK, E. B. Radiation oncology physics a handbook for teachers and students, In-ternational Atomic Energy Agency, Vienna, 2005.

INCA, Instituto Nacional do Câncer. INCA BR, 2017. Available at: <http://www2.inca.gov.br/wps/wcm/connect/cancer/site/oquee>. Last accessed: 11, July. 2017.

GRIMM P.D.; BLASKO J.C.; SYLVESTER J.E., M.D.; MEIER, R.M.; CAVANAGH W. 10-year biochemical (prostate-specific antigen) control of Prostate cancer with 125-I brachytherapy, Int J Radiat Oncol Biol Phys, v. 51, p. 31-40, 2001.

NOGUEIRA L.B.; CAMPOS T.P.R. Nuclear chatacterization and investigation of radioactive bioglass seed surfaces for brachytherapy via scanning electron microscopy. J of Sol-Gel Science and Technology, v. 58, p. 215-258, 2011.

NOGUEIRA, L.B.; CAMPOS, T.P.R. Radiological response of ceramic and polymeric devices for breast brachytherapy. Applied Radiation and Isotopes, v.70, p. 663-669, 2012.

NOGUEIRA L.B.; CAMPOS T.P.R. Synthesis, chemical characterization and radiological re-sponse of Ho and HoZr bioglass seeds. J of Sol-Gel Science and Technology, v. 77, p. 688-698, 2016.

VALENTE, E.S.; CAMPOS, T.P.R. Gamma spectrometry and chemical characterization of ce-ramic seeds with samarium-153 and holmium-166 for brachytherapy proposal, Applied Radiation and Isotopes, v.68, p. 2157-2162, 2010.

VALENTE, E.S.; CUPERSCHMID, E.M.; CAMPOS, T.P.R. Evaluation of hela cell lineage re-sponse to β radiation from Holmium-166 embedded in ceramic seeds. Brazilian Archives of Biol-ogy and Technology, v. 54, p. 957-964, 2011.

DINIZ, M.F.; FERREIRA, D.M.; WANDERSON, G.L.; PEDROSA, M.L.; SILVA, M.E.; ARAUJO, S.A.; SAMPAIO, K.H.; CAMPOS, T.P.R.; SIQUEIRA, S. L. Biodegradable seeds of holmium don’t change neurological function after implant in brain of rats. Reports of Practical Oncology & Radiotherapy, v. 22, p. 319-326, 2017.

CAMPOS, T.P.R.; NOGUEIRA, L.B.; TRINDADE, B.; CUPERSCHMID, E.M. Dosimetric intercomparison of permanent Ho-166 seed's implants and HDR Ir-192 brachytherapy in breast cancer. Reports of Practical Oncology & Radiotherapy, v. 21, p. 240-249, 2016.

LNHB, Laboratoire National Henri Becquerel. France, 2017. Available at: <http://www.nucleide.org/DDEP_WG/Nuclides/Ho-166_tables.pdf>. Last accessed: 27, May. 2017.

PEREZ, C.A. Technical Basis of Radiation Therapy, Springer, 2006. p. 275.

BENI, M. S.; NG C.Y.P, KRSTIC D., NIKEZIC D., YU K.N. Conversion coefficients for de-termination of dispersed photon dose during radiotherapy: NRUrad input code for MCNP. PloS one, 12.3 2017

TAGHAVI, R.; MIRZAEIET H. R.; AGHAMIRI S.M.R.; HAJIAN P. Calculating the absorbed dose by thyroid in breast cancer radiotherapy using MCNP-4C code. Radiation Physics and Chemistry, v.130, p. 12-14, 2017.

HADAD, K.; MAHDI S.; BANAFSHEH Z. Voxel dosimetry: Comparison of MCNPX and DOSXYZnrc Monte Carlo codes in patient specific phantom calculations. Technology and Health Care, v.25, p. 29-35, 2017.

PAPPAS, E. P., ZOROS E., MOUTSATSOS, A., PEPPPA, V., ZOURARI, K., KARAISKO, P., PAPAGIANNIS, P. On the experimental validation of model-based dose calculation algorithms for 192Ir HDR brachytherapy treatment planning. Physics in Medicine and Biology, v. 62, p. 41-60, 2017.

MOUNTRIS, K. A., BERT, J., NOAILLY, J., AGUILERA, R.A., VALERI, A., PRADIER, O., SCHICK, U., PROMAYON, E., BALLESTER, M.A.G. Modeling the impact of prostate edema on LDR brachytherapy: a Monte Carlo dosimetry study based on a 3D biphasic finite element biomechanical model. Physics in Medicine and Biology, v.62, p. 2087-2102, 2017.

FERREIRA, C. C.; GALVÃO, L. A.; VEIRA, J. W.; MAIA, A. F. Validação de um modelo computacional de exposição para dosimetria em tomografia computadorizada. Revista Brasileira de Física Médica, v. 4 , p. 19-22 ,2010.

X-5 MONTE CARLO TEAM. MCNP – A general Monte Carlo N-Particle transport code, v. 5.: Los Alamos National Laboratory, Los Alamos, NM, 2003.

TRINDADE, B. M. Desenvolvimento de sistema computacional para dosimetria em radio-terapia por nêutrons e fótons baseado em método estocástico SISCODES. Belo Horizonte, MG: Departamento de Engenharia Nuclear, Universidade Federal de Minas Gerais, 2004.

TRINDADE, B. M.; CHRISTOVÃO, M. T.; TRINDADE, D. F. M. ; FALCÃO, P. L. ; CAM-POS, T. P. R. . Comparative dosimetry of prostate brachytherapy with I-125 and Pd-103 seeds via SISCODES/MCNP. Radiologia Brasileira, v. 45, p. 267-272, 2012.