Monitoring internal contamination from OEW of an  18F-FDG production plant: WBC or head counting setup?

Bruno Melo Mendes; Bruno Machado Trindade; Telma Cristina Ferreira Fonseca; Tarcisio Passos Ribeiro de Campos

doi:10.15392/bjrs.v7i3A.880

Authors

Bruno Melo Mendes Centro de Desenvolvimento da Tecnologia Nuclear - CDTN/CNEN
Bruno Machado Trindade University of Ottawa. Ottawa, Ontario, Canada
Telma Cristina Ferreira Fonseca Universidade Federal de Minas Gerais – UFMG
Tarcisio Passos Ribeiro de Campos Universidade Federal de Minas Gerais – UFMG

DOI:

https://doi.org/10.15392/bjrs.v7i3A.880

Keywords:

Internal Dosimetry, MCNPx, VMC in-vivo, 18F-FDG incorporation

Abstract

The production ¹⁸F-FDG for positron emission tomography (PET) has consistently increased over the past two decades. The risk of internal contamination at ¹⁸F-FDG production facilities exists. A setup for evaluation of the ¹⁸F-FDG activity incorporated into the OEW brain, called Head Counting System (HCS), was presented in previous works. In this study, the whole body counter setup (WBC) was evaluated for monitoring ¹⁸F incorporations. The Monte Carlo Virtual Software (VMC in-vivo) and the MCNPx code were used to assess the system calibration coefficient (CC). Three ¹⁸F distributions were simulated: i) uniformly distributed in soft tissue (UDST); ii) Na¹⁸F biodistribution (NAFB); and iii) ¹⁸F-FDG biodistribution (FDGB). The calibration coefficient of WBC was compared to the current head counting system CC under the same biodistribution conditions. The ICRP male reference voxelized phantoms (RCP_AM) was used in the simulations. The results showed that the WBC setup was more efficient than the head counter for all the studied ¹⁸F distributions: UDST = 1060 %, FDGB = 488 % and NAFB = 340 %. Despite this, especially for ¹⁸F-FDG, the possibility of bladder voiding before measurement can lead to considerable uncertainties when the WBC setup is used. On the other hand, bladder activity does not show great influence the calibration coefficient of the head counting system. Future work will evaluate the WBC sources of uncertainties in the measurement of ¹⁸F incorporated activity.

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Author Biographies

Bruno Melo Mendes, Centro de Desenvolvimento da Tecnologia Nuclear - CDTN/CNEN

Pesquisador – Mat 00434-1

Seção de Dosimetria das Radiações – SECDOS

Telma Cristina Ferreira Fonseca, Universidade Federal de Minas Gerais – UFMG

Professora Adjunta

Departamento de Engenharia Nuclear - DEN

Tarcisio Passos Ribeiro de Campos, Universidade Federal de Minas Gerais – UFMG

Professor Titular

Departamento de Engenharia Nuclear - DEN

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