Estudo preliminar da dose absorvida e efetiva da cisplatina radiomarcada
DOI:
https://doi.org/10.15392/bjrs.v8i1.1147Keywords:
Cisplatina, Monte Carlo, dose absorvida e efetivaAbstract
A cisplatina ou cis-diaminodicloroplatina (II), [(NH)3PtCl2], é um quimioterápico amplamente utilizado em diversos tipos de neoplasias mas apresenta efeitos colaterais muitas vezes severos. Diversas formas alternativas de administração desta droga visando maior eficácia no tratamento tem sido investigadas. Uma delas é o possível uso da sinergia nos efeitos radioquimioterápicos obtidos com a aplicação da cisplatina radiomarcada. Para avaliar a viabilidade desta estratégia, neste trabalho foram estimadas as doses absorvidas nos tecidos e a dose efetiva devido à administração da cisplatina marcada, considerando apenas os emissores do radioisótopo 195mPt. Dados de biodistribuição disponíveis na literatura, fantomas voxelizados de referência da ICRP e métodos Monte Carlo foram utilizados nas simulações. Os maiores valores de dose absorvida no fantoma feminino foram observados nos rins (3,34 mGy/MBq), baço, (2,65 mGy/MBq) e fígado (2,21 mGy/MBq). No fantoma masculino as doses absorvidas foram observadas nos rins (2,96 mGy/MBq), baço, (2,31 mGy/MBq) e fígado (1,73 mGy/MBq). As doses efetivas por unidade de atividade injetada calculadas para a 195mPt foram de 0,29 mSv para a mulher e 0,24 mSv para o homem. O estudo de biodistribuição dos radioisótopos das platina é uma etapa preliminar estudos posteriores em modelo animal e avaliação da viabilidade de futuro uso clínico. A contribuição dos demais radioisótopos produzidos na irradiação direta da cisplatina está em análise, e será motivo de trabalho posterior.
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