Influence of image reconstruction protocols on the image quality of a small animal PET scanner using 18F and 11C

Authors

  • João Vitor do Carmo Barbosa Universidade Federal de Minas Gerais; Centro de Desenvolvimento da Tecnologia Nuclear.
  • Rodrigo Modesto Gadelha Gontijo Centro de Desenvolvimento da Tecnologia Nuclear.
  • Guilherme Cavalcante de Albuquerque Souza Universidade Federal de Minas Gerais; Centro de Desenvolvimento da Tecnologia Nuclear.
  • Bruno Melo Mendes Centro de Desenvolvimento da Tecnologia Nuclear.
  • Juliana Batista da Silva Centro de Desenvolvimento da Tecnologia Nuclear.
  • Marcelo Mamede Universidade Federal de Minas Gerais.
  • Andréa Vidal Ferreira Centro de Desenvolvimento da Tecnologia Nuclear.

DOI:

https://doi.org/10.15392/bjrs.v9i3.1734

Keywords:

Small Animal PET, Image Quality, NEMA NU 4-2008.

Abstract

The small animal positron emission tomography (PET) scanner from Molecular Imaging Laboratory (LIM/CDTN) is dedicated to pre-clinical studies on new 18F and 11C-based radiopharmaceuticals and to development of novel applications for well-known radiopharmaceuticals. Thus, quality control tests recommended by the publication NEMA NU 4-2008 are routinely carried out to ensure the proper performance of PET scanner. The aim of this work was to evaluate the influence of image reconstruction protocols on the image quality, accuracy of attenuation and scatter corrections parameters for 18F and 11C PET images. PET images of the image quality phantom filed with 18F-FDG or 11C-PK1122 were acquired and then reconstructed using different reconstruction protocols. The reconstruction variables evaluated were the algorithms (FBP, MLEM-3D, OSEM-3D), the resolution mode (high/standard) and the number of iterations (10 to 150). Uniformity, spill-over ratio (SOR) and recovery coefficients (RC) tests were performed for each reconstructed image according NEMA NU 4-2008. PMOD software was used for image analysis. FBP based protocol generated noisier images compared to iterative algorithms (MLEM-3D or OSEM-3D) based protocols. The increase in the number of iterations resulted in higher standard deviation of the analyzed parameters for all reconstructed images. MLEM-3D and OSEM-3D based protocols generates similar results when number of iterations and resolution mode were identical. SOR and RC mean values remained stable when the number of iterations ranged from 40 to 150. This study allowed the evaluation of different image reconstruction protocols on important parameters of 18F and 11C PET image quality. Additionally, standard image reconstruction protocols to be adopted in LIM/CDTN laboratorial routine for 18F and 11C images reconstruction in preclinical studies were defined.

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References

R. YAO, R.; LECOMTE, R.; CRAWFORD, E. Small-Animal PET: What is it, and why do we need it? Journal of Nuclear Medicine Technology. Vol. 40 nº3, pp.157-165. 2011.

NEMA, National Eletrical Manufacturers Association, “Performance Measurements of Small Animal PET”, Rosslyn VA; Standards Publication NU 4-2008, 2008.

GE Healthcare, Triumph Service Guide, Technical Publication, © GE Healthcare, Revision Draft 6, USA (2011).

TRETRAULT M. A., et al. System architecture of the LabPET small animal PET scanner. IEEE Transactions on Nuclear Science, 2008. v.55, p. 2546-2550.

FONTAINE R., et al. The hardware and signal processing architecture of LabPET™, a small animal APD-based digital PET scanner. IEEE Transactions on Nuclear Science, February 2009. v. 56, p. 3-9.

Gamma Medica-Ideas, User Manual: Positron Emission Tomography (PET) Scanner Software - Manual for Acquisition and Processing of PET Images from the LABPET System.

BELCARI, N. et al., NEMA NU-4 Performance Evaluation of the IRIS PET/CT Preclinical Scanner. IEEE Transactions on Nuclear Science. 2017. v. 1. p. 301-309. 2017.

GONTIJO, R. M. G., et al. Image quality evaluation of a small animal PET scanner. Brazilian Journal of Radiation Sciences. v. 8-01. p. 01-13, 2020.

PMOD Tecnologies LCC, PMOD v.3.7. User Manual. 2015.

IAEA - International Atomic Energy Agency. Live Chart of Nuclides. https://www-nds.iaea.org/relnsd/vcharthtml/VChartHTML.html. 2020.

DEFRISE, Michel & Kinahan, Paul & Michel, Christian. (2006). Image Reconstruction Algorithms in PET. 10.1007/1-84628-007-9_4.

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Published

2021-09-20

How to Cite

Barbosa, J. V. do C., Gontijo, R. M. G., Souza, G. C. de A., Mendes, B. M., Silva, J. B. da, Mamede, M., & Ferreira, A. V. (2021). Influence of image reconstruction protocols on the image quality of a small animal PET scanner using 18F and 11C. Brazilian Journal of Radiation Sciences, 9(3). https://doi.org/10.15392/bjrs.v9i3.1734

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