18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom

Andréa Vidal Ferreira; Ana Carolina Araujo Bispo; Christiane Silva Leite; Juliana Batista da Silva; Marcelo Mamede; Rodrigo Modesto Gadelha Gontijo; Bruno Melo Mendes

doi:10.15392/2319-0612.2022.2089

Authors

Andréa Vidal Ferreira Centro de Desenvolvimento da Tecnologia Nuclear CDTN/CNEN https://orcid.org/0000-0001-7698-4323
Ana Carolina Araujo Bispo Centro de Desenvolvimento da Tecnologia Nuclear https://orcid.org/0000-0002-1934-9881
Christiane Silva Leite Centro de Desenvolvimento da Tecnologia Nuclear https://orcid.org/0000-0003-3336-8912
Juliana Batista da Silva Centro de Desenvolvimento da Tecnologia Nuclear https://orcid.org/0000-0002-0794-1896
Marcelo Mamede Universidade Federal de Minas Gerais (UFMG) https://orcid.org/0000-0001-5818-0954
Rodrigo Modesto Gadelha Gontijo Universidade Federal de Minas Gerais (UFMG) https://orcid.org/0000-0001-6479-3087
Bruno Melo Mendes Centro de Desenvolvimento da Tecnologia Nuclear https://orcid.org/0000-0002-8914-8022

DOI:

https://doi.org/10.15392/2319-0612.2022.2089

Keywords:

radiation dosimetry,, 18F-FES, preclinical studies

Abstract

Small animals, such as mice, are used in radiopharmaceutical biodistribution studies and innumerous others preclinical investigations involving ionizing radiation. Longitudinal preclinical studies with five or more image procedures, involving radiopharmaceuticals injection and/or X-radiation, are not uncommon. However, a suitable dosimetric evaluation is not always available and, sometimes, absorbed doses in animal organs or tissues and their influence in experimental results were not appropriately taken into account. Accurate calculation of absorbed doses in mice organs are needed to evaluate potential radiobiological effects that may interfere with in vivo experiments. In this work, we perform a preliminary 16α-[¹⁸F]-fluoro-17β-estradiol (¹⁸F-FES) radiation dosimetry estimates for female mice. The obtained animal dosimetric results can be useful for evaluating animal doses during the design of longitudinal preclinical studies.

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