Study of emission of radioactive gaseous effluents in the production of 18F-FDG
DOI:
https://doi.org/10.15392/bjrs.v7i3.892Keywords:
Radiopharmaceuticals PET, Radioactive Air contamination, Monitoring air flow.Abstract
The number of units producing radiopharmaceuticals with a half-life of fewer than two hours has increased with the growth of PET technology in Brazil. In the production of such radiopharmaceuticals such as 18F-FDG or 11C-PIB, gaseous waste is formed. The International Atomic Energy Agency (IAEA) proposes a methodology that can be used to evaluate the dispersion of these gaseous effluents. This work has retrospectively evaluated the emission of radioactive gaseous effluents generated in the production of 18F-FDG, in order, to delimit yield values of radioactive waste in the gaseous form and to verify the effectiveness and the design of the safety elements of the exhaust system evaluated before the standards of the National Nuclear Energy Commission (CNEN) and IAEA recommendations. Thirty-six productions of 18F-FDG were found.
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References
Rocha, A. F. G., Medicina Nuclear: aplicações clínicas, 1º Ed., Editora Guanabara Koogan. Rio de Janeiro. 1976.
Saha, G. B., Fundamentals of Nuclear Pharmacy, 6ª Ed., 2010.
Facure et al, Licenciamento de Laboratórios Produtores de Radioisótopos com cíclotrons no Brasil, Comissão Nacional de Energia Nuclear, 2012.
www. cnen.gov.br. Acessado em 28/12/2018.
CALANDRINO, R., del VECCHIO, A., TODDE, S., FAZIO, F. Measurement and Control of the Air
Contamination Generated In a Medical Cyclotron Facility for PET Radiopharmaceuticals. The Radiation Safety Journal,
vol.92, suppl. 2, p.70-77, 2007.
CNEN. Comissão Nacional de Energia Nuclear. Gerencia de Rejeitos Radioativos. Rio de Janeiro, Brasil: CNEN
NN 8.01, 2014.
INTERNATIONAL ATOMIC ENERGY AGENCY . Safety Reports Series Nº 19. Generic Models for Use in
Assessing the Impact of discharges of Radioactive Substances to the Environment, Viena, 2001.
Júnior, J. S., et al, Lista de Recomendações do Exame PET/CT com 18F-FDG em Oncologia. Consenso entre a
Sociedade Brasileira de Cancerologia e a Sociedade Brasileira de Biologia, Medicina Nuclear e Imagem Molecular,
Radiol Bras. 2010 Jul/Ago;43(4):255–259.
CNEN. Comissão Nacional de Energia Nuclear. Diretrizes Básicas de Proteção Radiológica. Rio de Janeiro, Brasil:
CNEN-NN-3.01, 2005.
CNEN. Comissão Nacional de Energia Nuclear. Licenciamento de Instalações Radiativas. Rio de Janeiro, Brasil:
CNEN-NE 6.02, 1998.
CDTN. Programa de Monitoração Ambiental do CDTN. Belo Horizonte: PMA / CDTN, 2008.
INTERNATIONAL ATOMIC ENERGY AGENCY. Technical Reports Series No. 465, Cyclotron Produced
Radionuclides: Principles and Practice, Viena, 2008
INTERNATIONAL ATOMIC ENERGY AGENCY. Technical Reports Series No. 468, CYCLOTRON
PRODUCED RADIONUCLIDES: PHYSICAL CHARACTERISTICS AND PRODUCTION METHODS, Viena, 2009.
IAEA. International Atomic Energy Agency. International Basic Safety Standards for protection against ionizing
radiation and for the safety of radiation sources. IAEA, Viena: BSS Safety Series 115, 1996.
IAEA. International Atomic Energy Agency. Generic procedures for assessment and response during a radiological
emergency. IAEA, Viena: TECDOC 1162, 2000.
INTERNATIONAL ATOMIC ENERGY AGENCY. IAEA RADIOISOTOPES AND
RADIOPHARMACEUTICALS SERIES No. 4, Cyclotron Produced Radionuclides: Operation And Maintenance Of
Gas And Liquid Targets, Viena, 2012.
CASTELHANO, F. J.; ROSEGHINI, W. F. F. Caracterização da dinâmica dos ventos em Curitiba-PR. Geousp
Espaço e Tempo (Online), v. 22, n. 1, p. 227-240, 2018. ISSN 2179-0892.
Manual do fabricante. Rotem MediSmarts Stack Monitor. Calibration Procedure, 2012.
Manual do Fabricante. PETtrace 800 series, Service Manual – Accelerator-Rev. 20.
IAEA - International Atomic Energy Agency. Cyclotron produced radionuclides: guidance on facility design and production of [18f] fluorodeoxyglucose (FDG). Vienna: IAEA, 2012. (Radioisotopes and Radiopharmaceuticals Series, nº 3).
Videira, H.S. Implantação de um processo comercial de produção de doses do radiofármaco 18F-FDG. Dissertação apresentada para obtenção do grau de mestre em ciências na área de engenharia. UFPR/PR. 2014.
Kleck JH, Benedict SH, Cook JS, Birdsall RL, Satyamurthy N., Assessment of 18F gaseous releases during the production of 18F-fluorodeoxyglucose, Health Phys. 1991 May;60(5):657-60.
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