On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route

Authors

  • Guilherme Soares Zahn Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP https://orcid.org/0000-0003-3237-8588
  • Frederico Antonio Genezini Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
  • Paulo Sérgio Cardoso da Silva Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
  • Renata Mendes Nory Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
  • Edson Gonçalves Moreira Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
  • Paulo Sérgio Santiago Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)

DOI:

https://doi.org/10.15392/bjrs.v9i1A.1411

Keywords:

Lu-177, radioisotope production

Abstract

Over the last years the 177Lu radioisotope has attracted great interest for the use in therapeutic and diagnostic procedures simultaneously, being what is now called a theranostic radioisotope. There are mainly two ways of producing this radioisotope, by direct neutron capture in a 176Lu target (the “direct route") or by irradiating a 176Yb sample, producing 177Yb that will then decay to 177Lu (also referred as the “indirect route”). In this work the feasibility of producing 177Lu in the IEA-R1 nuclear reactor via the direct route was assessed, and the specific activity that could be obtained was estimated both experimentally and theoretically, allowing for a discussion on the feasibility of commercially producing 177Lu by 176Lu neutron capture in the IEA-R1 reactor.

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Author Biographies

  • Guilherme Soares Zahn, Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
    Centro do Reator de Pesquisas - CERPQ
  • Frederico Antonio Genezini, Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
    Centro do Reator de Pesquisas - CERPQ
  • Paulo Sérgio Cardoso da Silva, Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
    Centro do Reator de Pesquisas - CERPQ
  • Renata Mendes Nory, Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
    Centro do Reator de Pesquisas - CERPQ
  • Edson Gonçalves Moreira, Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
    Centro do Reator de Pesquisas - CERPQ
  • Paulo Sérgio Santiago, Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
    Centro do Reator de Pesquisas - CERPQ

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Published

2021-04-30

Issue

Section

The Meeting on Nuclear Applications (ENAN) 2019

How to Cite

On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route. Brazilian Journal of Radiation Sciences, Rio de Janeiro, Brazil, v. 9, n. 1A, 2021. DOI: 10.15392/bjrs.v9i1A.1411. Disponível em: https://bjrs.org.br/revista/index.php/REVISTA/article/view/1411. Acesso em: 22 dec. 2024.

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