On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route

Authors

  • Guilherme Soares Zahn Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP https://orcid.org/0000-0003-3237-8588
  • Frederico Antonio Genezini Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
  • Paulo Sérgio Cardoso da Silva Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
  • Renata Mendes Nory Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
  • Edson Gonçalves Moreira Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
  • Paulo Sérgio Santiago Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)

DOI:

https://doi.org/10.15392/bjrs.v9i1A.1411

Keywords:

Lu-177, radioisotope production

Abstract

Over the last years the 177Lu radioisotope has attracted great interest for the use in therapeutic and diagnostic procedures simultaneously, being what is now called a theranostic radioisotope. There are mainly two ways of producing this radioisotope, by direct neutron capture in a 176Lu target (the “direct route") or by irradiating a 176Yb sample, producing 177Yb that will then decay to 177Lu (also referred as the “indirect route”). In this work the feasibility of producing 177Lu in the IEA-R1 nuclear reactor via the direct route was assessed, and the specific activity that could be obtained was estimated both experimentally and theoretically, allowing for a discussion on the feasibility of commercially producing 177Lu by 176Lu neutron capture in the IEA-R1 reactor.

Downloads

Download data is not yet available.

Author Biographies

  • Guilherme Soares Zahn, Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
    Centro do Reator de Pesquisas - CERPQ
  • Frederico Antonio Genezini, Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
    Centro do Reator de Pesquisas - CERPQ
  • Paulo Sérgio Cardoso da Silva, Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
    Centro do Reator de Pesquisas - CERPQ
  • Renata Mendes Nory, Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
    Centro do Reator de Pesquisas - CERPQ
  • Edson Gonçalves Moreira, Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
    Centro do Reator de Pesquisas - CERPQ
  • Paulo Sérgio Santiago, Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP)
    Centro do Reator de Pesquisas - CERPQ

References

DAS, T. ; BANERJEE, S. Theranostic Applications of Lutetium-177 in Radionuclide Therapy, Curr Radiopharm v.9, p. 94–101, 2016.

JING, L.; SHI, J.; FAN, D.; LI, Y.; LIU, R.; DAI, Z.; WANG, F.; TIAN, J. 177Lu-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics, ACS Appl. Mater. Interfaces, v. 7, p. 22095–22105, 2015.

PERSSON, M.; JUHL, K.; RASMUSSEN, P.; BRANDT-LARSEN, M.; MADSEN, J.; PLOUG, M.; KJAER, A. uPAR Targeted Radionuclide Therapy with 177Lu-DOTA-AE105 Inhibits Dissemination of Metastatic Prostate Cancer, Mol. Pharmaceutics, v. 11, p. 2796–2806, 2014;

KONDEV, F. G. Nuclear Data Sheets for A = 177, Nuclear Data Sheets, v. 98, p. 801–1095, 2003.

MUGHABGHAB, S. F. Thermal Neutron Capture Cross Sections Resonance Integrals And G-Factors - INDC(NDS)-440, Vienna :IAEA, 2003.

DVORAKOVA, Z.; HENKELMANN, R.; LIN, X.; TÜRLER, A,; GERSTENBERG, H. Production of 177Lu at the new research reactor FRM-II: Irradiation yield of 176Lu(n, γ)177Lu, Appl Radiat Isot, v. 66, p. 147–151, 2008.

KOPECKY, J. NGATLAS - Atlas of Neutron Capture Cross Sections, Vienna :IAEA, 2001. Available at: <https://www-nds.iaea.org/ngatlas2/>. Last accessed 15 May 2020.

KOYAMA, M.; MATSHUSHITA, R. Use of Neutron Spectrum Sensitive Monitors for Instrumental Neutron Activation Analysis, Bulletin of the Institute for Chemical Research, Kyoto University, v. 58, p. 235–243, 1980.

HØGDAHL, O. T. Neutron absorption in pile neutron activation analysis - Report MMPP-226-1, Ann Arbor:University of Michigan, 1962.

WESTCOTT, C. H. Effective cross section values for well moderated thermal reactor spectra - Report AECL-1101, Chalk River : Chalk River Laboratory, 1960.

COURSEY, J. S. ; SCHWAB, D. J. ; TSAI, J. J. ; DRAGOSET, R. A. Atomic Weights and Isotopic Compositions with Relative Atomic Masses, NIST, 2015. Available at : <https://physics.nist.gov/comp>. Last accessed 15 May 2020.

HOLDEN, N. E. Temperature dependence of the Westcott g-factor for neutron reactions in activation analysis, Pure Appl. Chem., v. 71, p. 2309–2315, 1999.

DE CORTE, F.; SIMONITS, A. Recommended nuclear data for use in the k0 standardization of neutron activation analysis, Atomic Data Nucl. Data Tables, v. 85, p. 47 67, 2003.

PILLAI, M.R.A.; CHAKRABORTY, S. ; DAS, T. ; VENKATESH, M. ; RAMAMOORTHY, N. Production logistics of 177Lu for radionuclide therapy, Appl Radiat Isot, v. 59, p. 109–118, 2003.

CHAKRABORTY, S. ; VIMALNATH, K.V.; LOHAR, S.P. ; SHETTY, P. ; DASH, A. On the practical aspects of large-scale production of 177Lu for peptide receptor radionuclide therapy using direct neutron activation of 176Lu in a medium flux research reactor: the Indian experience, J Radioanal Nucl Chem, v. 302, p. 233–243, 2014.

Downloads

Published

2021-04-30

Issue

Section

The Meeting on Nuclear Applications (ENAN) 2019

How to Cite

On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route. Brazilian Journal of Radiation Sciences, Rio de Janeiro, Brazil, v. 9, n. 1A, 2021. DOI: 10.15392/bjrs.v9i1A.1411. Disponível em: https://bjrs.org.br/revista/index.php/REVISTA/article/view/1411.. Acesso em: 17 nov. 2024.

Similar Articles

1-10 of 526

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)

1 2 3 > >>