Effect of COVID 19 vaccination on the CT severity score for SARS CoV2 pneumonia- an experience from the initial wave.
DOI:
https://doi.org/10.15392/2319-0612.2023.2279Keywords:
COVID-19, Vaccination, CTSSAbstract
The severe acute respiratory syndrome coronavirus 2 pandemic started in the December of 2019 at China. The second wave of the pandemic in India peaked between April-May 2021. In order to reduce the transmission and infectivity of the virus several vaccines were approved for emergent use. Studies have shown the effectiveness of vaccination in reducing the clinical severity of infection by the corona virus. In this study we aim to assess the effect of vaccination on the computed tomography severity score (CTSS). The study included 140 patients who tested positive for COVID 19 on RT PCR or rapid antigen test. Seventy of these patients had received at least one dose of vaccination and 70 patients were unvaccinated. CT scan of the chest was done for all patients and a CTSS ranging from 0 to 25 was assigned depending on the extent of lobar involvement. We found that a higher percentage (72.86%) of unvaccinated patients had severe disease compared to the vaccinated group (38.57%), 5.71% of unvaccinated patients had mild disease compared to 30% of vaccinated patients. The difference between the two groups was found to be statistically significant. On comparing the CTSS of patients with and without vaccination in our study, we found a significant reduction in the severity scores in the vaccinated group. Through this study the vaccine’s efficacy could be validated objectively. This article aims to emphasize the role of vaccination in our fight against the pandemic caused by the corona virus.
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References
World Health Organization. Weekly epidemiological update on COVID-19. https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19-19-october-2022
Kumar VM, Pandi-Perumal SR, Trakht I, Thyagarajan SP. Strategy for COVID-19 vaccination in India: the country with the second highest population and number of cases. npj Vaccines. 2021 Apr 21;6(1):1-7.
Centers for Disease Control and Prevention. The possibility of COVID-19 after vaccination: breakthrough infections. https://www.cdc.gov/ coronavirus/2019-ncov/vaccines/effectiveness/why-measure-effectiveness/ breakthrough-cases.html. Published September 7, 2021. Accessed November 3, 2021.
Rana EA, Dutta P, Islam MS, Nizami TA, Das T, Chowdhury S, Das GB. Severity assessment of single dose Oxford–AstraZeneca vaccinated individuals infected with SARS CoV-2 in the Southeast Bangladesh. medRxiv. 2021 Jan 1.
Glampson B, Brittain J, Kaura A, Mulla A, Mercuri L, Brett S, Aylin P, Sandall T, Goodman I, Redhead J, Saravanakumar K. North West London Covid-19 Vaccination Programme: Real-world evidence for Vaccine uptake and effectiveness. medRxiv. 2021 Jan 1.
Francone M, Iafrate F, Masci GM, Coco S, Cilia F, Manganaro L, Panebianco V, Andreoli C, Colaiacomo MC, Zingaropoli MA, Ciardi MR. Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis. European radiology. 2020 Dec;30(12):6808-17.
Kwee TC, Kwee RM. Chest CT in COVID-19: what the radiologist needs to know. RadioGraphics. 2020 Nov;40(7):1848-65.
Henkel M, Weikert T, Marston K, Schwab N, Sommer G, Haslbauer J, Franzeck F, Anastasopoulos C, Stieltjes B, Michel A, Bremerich J. Lethal COVID-19: Radiologic-Pathologic Correlation of the Lungs. Radiology: Cardiothoracic Imaging. 2020 Nov 19;2(6):e200406.
Lee JE, Hwang M, Kim YH, Chung MJ, Sim BH, Chae KJ, Yoo JY, Jeong YJ. Imaging and Clinical Features of COVID-19 Breakthrough Infections: A Multicenter Study. Radiology. 2022 Jun;303(3):682-92.
Singh AK, Phatak SR, Singh R, Bhattacharjee K, Singh NK, Gupta A, Sharma A. Antibody response after second-dose of ChAdOx1-nCOV (Covishield™®) and BBV-152 (Covaxin™®) among health care workers in India: final results of cross-sectional coronavirus vaccine-induced antibody titre (COVAT) study. medRxiv. 2021 Jan 1.
Kovács A, Palásti P, Veréb D, Bozsik B, Palkó A, Kincses ZT. The sensitivity and specificity of chest CT in the diagnosis of COVID-19. European Radiology. 2021 May;31(5):2819-24.
Gurumurthy B, Das SK, Shetty S, Veerabhadrappa RC, Kosinepalli SS, Dharamaraju SH. CT severity score: an imaging biomarker to estimate the severity of COVID-19 pneumonia in vaccinated and non-vaccinated population. Egyptian Journal of Radiology and Nuclear Medicine. 2022 Dec;53(1):1-8.
Atre AL, Atre A, Panchawagh S, Khamkar R, Chandorkar A, Patil S. Association between Chest CT Severity Scores and SARS-CoV-2 Vaccination among COVID-19 patients: A Cross-sectional Study from Pune, India. Journal of Clinical & Diagnostic Research. 2022 Jun 1;16(6).
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