Detection limit calculation according to ISO 11929 for in vitro 210Pb radiobioassay determinations by LSC
DOI:
https://doi.org/10.15392/2319-0612.2023.2185Keywords:
detection limit, 210Pb, LSCAbstract
According to the limit of detection (DL) presented in ISO 11929:2010, the International Organization for Standardization (ISO) abandoned the concept of minimum detectable amount (MDA) described in ISO 12790-1:2001. In this work we demonstrate and discuss how we calculate the detection limit for the determination of 210Pb by liquid scintillation counter (LSC) for the previously developed methodology and compare its results with the MDA value. The DL value found was 0.033 Bq/L instead of 0.032 Bq/L for MDA. The MDA and LD values did not differ virtually, the results highlight that the main change between the two Standard is related to the definition approach.
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ISO 12790-1:2001. Performance criteria for radiobioassay — Part 1: General principles. <https://www.iso.org/standard/32473.html>
ISO 11929:2010. Determination of the characteristic limits (decision threshold, detection limit and limits of the confidence interval) for measurements of ionizing radiation — Fundamentals and application. < https://www.iso.org/standard/43810.html>
ISO 28218:2010. Performance criteria for Radiobioassay. <https://www.iso.org/standard/40869.html>
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