Characterization of applicator material for treatment of superficial lesions in brachytherapy
DOI:
https://doi.org/10.15392/2319-0612.2024.2611Palabras clave:
Brachytherapy, superficial lesions, dimethyl polysiloxane, applicatorResumen
The treatment of superficial lesions by brachytherapy is performed using radioactive sources positioned inside tumors or at a short distance from them, to deposit the prescribed dose in the target volume. In the case of treating skin lesions, due to the proximity between the source and the patient's surface, it is important to use applicators that conduct the radiation source to the region to be treated, ensuring the safety and hygiene of the process. The treatment of keloids, for example, can be performed by brachytherapy. Considering that the applicators must undergo rigorous quality control, this study presents an evaluation of an applicator developed for the treatment of skin lesions, consisting of fifteen spheres of synthetic material, for use in High dose rate brachytherapy (HDR) equipment, model Nucletron Digital V3, equipped with an Ir-192 source. It was considered important to determine whether the spheres are suitable for medical use, direct contact with the patient's skin and sterilization methods. Furthermore, it was necessary to consider the material's resistance to the irradiation process, since the spheres must be used in multiple applications. In this sense, it was necessary to define the material of the spheres and, through this characterization, consider their suitability for the proposed use. Since the spheres were acquired with generic specifications, this study aimed to perform analyses to characterize the material, defining its composition. Consequently, the focus was to evaluate their safe use in the brachytherapy applicator.
Descargas
Referencias
[1] SALVAJOLI, J. V. et al. Radioterapia em Oncologia. 2. ed. São Paulo: Atheneu, 2013. p. 161-218. ISBN-10. 8538803816.
[2] SKOWRONEK, J. Brachytherapy in the treatment of skin cancer: an overview. Advances in Dermatology and Allergology/Post¸epy Dermatologii i Alergologii, Termedia Publishing, v. 32, n. 5, p. 362-367, 2015.
[3] DAURADE, M. et al. Efficacy of surgical excision and brachytherapy in the treatment of keloids: A retrospective cohort study. Advances in Skin & Wound Care, LWW, v. 33, n. 11, p. 1–6, 2020.
[4] OHTA, M. et al. Verification of evaluation accuracy of absorbed dose in the dose-evaluation system for Iridium-192 brachytherapy for treatment of keloids. Biomedical Physics & Engineering Express, IOP Publishing, v. 4, n. 2, p. 025022, 2018.
[5] BIJLARD, E. et al. Burden of keloid disease: a cross-sectional health-related quality of life assessment. Acta dermato-venereologica, v. 97, n. 2, p. 225–229, 2017.
[6] HOANG, D. et al. Surgical excision and adjuvant brachytherapy vs external beam radiation for the effective treatment of keloids: 10-year institutional retrospective analysis. Aesthetic surgery journal, Oxford University Press, v. 37, n. 2, p. 212–225, 2017.
[7] KHAN, F. M.; GIBBONS, J. P. Khan’s the physics of radiation therapy. 5. ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2014. ISBN 978-1-4511-8245-3.
[8] WEN, A. et al. Comparative Analysis of 60Co and 192Ir Sources in High Dose Rate Brachytherapy for Cervical Cancer. Cancers, v. 14, n. 19, 2022. ISSN 2072-6694.
[9] ALMUQRIN, A. H. et al. Exploring the impact of Bi2O3 particle size on the efficacy of dimethylpolysiloxane for medical gamma/X-rays shielding applications. Radiation Physics and Chemistry, v. 220, p. 111629, 2024.
[10] GOUDA, M. M.; ZARD, K. An extensive investigation on gamma shielding properties of dimethylpolysiloxane modified with nano sized SnO2 and CdO. Radiation Physics and Chemistry, v. 218, p. 111588, 2024.
[11] GOUDA, M. M. et al. Nano tin oxide/dimethyl polysiloxane reinforced composite as a flexible radiation protecting material. Scientific Reports, v. 13, n. 1, p. 210, 2023.
[12] DONG, F. et al. Thermal degradation kinetics of functional polysiloxane with pendent γ-chloropropyl groups. Polymer Bulletin, v. 78, p. 1-14, 2021.
[13] STEINBACH, J. C. et al. A process analytical concept for in-line FTIR monitoring of polysiloxane formation. Polymers, v. 12, n. 11, p. 2473, 2020.
[14] WÓJCIK-BANIA, M. Influence of the addition of organo-montmorillonite nanofiller on cross-linking of polysiloxanes–FTIR studies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, v. 252, p. 119491, 2021.
[15] DESHPANDE, G., REZAC, M. E. Kinetic aspects of the thermal degradation of poly (dimethyl siloxane) and poly (dimethyl diphenyl siloxane). Polymer Degradation and Stability, v. 76, n. 1, p. 17-24, 2002.
[16] REDONDO, S. U. A. et al. Estudo da decomposição térmica de compósitos fibras de celulose/silicona. In: Proceedings of the 2002 Congresso Brasileiro de Engenharia e Ciências dos Materiais, Natal, 09 a 13 de novembro, vol. 1, pp. 1692-1698, 2002.
[17] LIU, B. et al. Gamma irradiation-induced degradation of silicone encapsulation. Materials Today Communications, v. 31, p. 103476, 2022.
[18] TALLEY, S. J. et al. Flexible 3D printed silicones for gamma and neutron radiation shielding. Radiation Physics and Chemistry, v. 188, p. 109616, 2021.
[19] MAEYAMA, T. et al. Development of a silicone-based radio-fluorogenic dosimeter using dihydrorhodamine 6G. Physica Medica, v. 114, p. 102684, 2023.
[20] CARTURAN, S. M. et al. Additive manufacturing of high-performance, flexible 3D siloxane-based scintillators through the sol-gel route. Applied Materials Today, v. 39, p. 102313, 2024.
Descargas
Publicado
Número
Sección
Categorías
Licencia
Derechos de autor 2024 Juan Carlos Chrisostomo Lamônica, Marcela Morais Freitas, Mariana Oliveira Reis, Luciana Batista Nogueira, Jony Marques Geraldo, Clara B Nascimento, Arnoldo Mafra, Adriana de Souza Medeiros Batista

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Licencia: los artículos de BJRS tienen una licencia internacional Creative Commons Attribution 4.0, que permite el uso, el intercambio, la adaptación, la distribución y la reproducción en cualquier medio o formato, siempre que se otorgue el crédito correspondiente al autor o autores originales y a la fuente, proporcione un enlace a la licencia Creative Commons e indique si se realizaron cambios. Las imágenes u otros materiales de terceros en el artículo están incluidos en la licencia Creative Commons del artículo, a menos que se indique lo contrario en una línea de crédito al material. Si el material no está incluido en la licencia Creative Commons del artículo y su uso previsto no está permitido por la regulación legal o excede el uso permitido, el autor deberá obtener el permiso directamente del titular de los derechos de autor. Para ver una copia de esta licencia, visite http://creativecommons.org/licenses/by/4.0/