Verification of absorbed dose in blood component cases using radiochromic film EBT3

Abstract

Dosimetry of blood components is an essential practice to ensure the safety and efficacy of irradiation in blood products, serving as a fundamental measure to quantify and map the absorbed radiation doses. This study addresses dosimetric procedures using EBT3 radiochromic films according to ISO/ASTM 51939:2017 to ensure compliance with established dose standards. The methodology includes obtaining calibration curves for different absorbed dose values, mapping storage containers, and determining the optimal dose for irradiations using pre-calibrated radiochromic films with a margin of uncertainty of ±10%, based on the standards of the Gamma Irradiation Laboratory (LIG/CDTN). The irradiations were carried out in a Category II Multipurpose Panoramic Irradiator using a Cobalt-60 source. The films were positioned inside and outside the cases used for storing blood and components. The results demonstrate compliance with ISO/ASTM standards and ANVISA regulations, validating the efficacy of the quality assurance program, with a uniform distribution of absorbed doses in the analyzed containers. Data analysis shows that the absorbed dose variation is within established limits, ensuring that the components receive a minimum dose of 15 Gy and do not exceed the maximum dose of 50 Gy. Furthermore, the results indicate that the average absorbed dose was slightly below the fixed value of 25 Gy recommended by ANVISA, possibly due to the shielding effect of present materials. This study provides a solid basis for the continuous improvement of blood and blood component irradiation processes, ensuring that patients receive safe and effective treatments.