New article published in 12(4A) - ENAN / INAC 2024

In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysis

Abstract: This study evaluated the biodistribution of gum arabic-functionalized gold nanoparticles (GA-AuNPs) in Balb/C Nude mice following intravenous administration. Two activity regimens (200 µCi and 600 µCi) were analyzed at two different time points (3 and 24 hours post-injection). The results showed predominant accumulation of GA-AuNPs in the liver, spleen, and gallbladder, suggesting hepatobiliary excretion as the primary clearance route. A reduction in liver uptake after 24 hours indicates potential nanoparticle metabolism or elimination. Although this study focused on intravenous delivery, previous work from our group using BSA-coated AuNPs administered intratumorally demonstrated higher tumor retention and reduced systemic accumulation, reinforcing the importance of administration route and surface coating in defining nanoparticle biodistribution. These findings contribute to the understanding of how delivery strategy influences nanoparticle bioavailability and support the development of safer and more targeted therapeutic platforms.  Read full article. 

Typical value of the mean glandular dose in Full-field Digital mammography at the Public Hospital in Brazil

Abstract:  The mean glandular dose (MGD) provides dosimetric information about the quantity of radiation received by the mammary glands during mammographic exposures. There is, therefore, the need to analyse the radiation dose received by patients presenting for mammography examinations. This study presents the establishment of typical values for the mean glandular dose (MGD) in full-field digital mammography (FFDM) in a public hospital in Brasil. The research responds to the International Commission on Radiological Protection (ICRP) guidelines and aims to optimize radiation doses while ensuring the diagnostic quality of mammograms. By analyzing DICOM images obtained from patients, typical MGD values were calculated for different compressed breast thicknesses (CBT). The study involves a comprehensive review of exposure parameters and patient data, extracted via the Volpara Manager Dose software and DICOM Header. The results provide an essential reference for local Diagnostic Reference Levels (DRLs) in mammography, supporting ongoing efforts to enhance imaging safety and image quality. These findings also provide a framework for the future implementation of local DRLs across public hospitals, emphasizing the importance of consistent radiation dose management in mammography. Read full article.