Determination of the total retention capacity of 99Mo in anionic extracting agent

Ione Makiko Yamazaki; Denise Simoes Moreira; Mauro da Silva Dias; José Antonio Seneda; Marina Fallone Koskinas

doi:10.15392/2319-0612.2024.2657

Authors

Ione Makiko Yamazaki Instituto de Pesquisas Energéticas e Nucleares IPEN-CNEN/SP , Nuclear Energy Research Institute
Denise Simoes Moreira Instituto de Pesquisas Energéticas e Nucleares IPEN-CNEN/SP , Nuclear Energy Research Institute
Mauro da Silva Dias Instituto de Pesquisas Energéticas e Nucleares IPEN-CNEN/SP , Nuclear Energy Research Institute
José Antonio Seneda Instituto de Pesquisas Energéticas e Nucleares IPEN-CNEN/SP , Nuclear Energy Research Institute
Marina Fallone Koskinas Instituto de Pesquisas Energéticas e Nucleares IPEN-CNEN/SP , Nuclear Energy Research Institute

DOI:

https://doi.org/10.15392/2319-0612.2024.2657

Keywords:

: 99Mo, anionic extracting agent, breakthrough curve

Abstract

The Nuclear Metrology Laboratory (LMN) at IPEN-CNEN/SP is developing a research project aimed at studying analytical techniques for determining radioactive impurities, emitting alpha and beta particles. This project started with the determination of impurities present in ⁹⁹Mo, which is used to obtain the radiopharmaceutical ^99mTc by means of radiochemical separation in the ⁹⁹Mo/^99mTc generator. The study of the anionic extracting agent Strata X-A widely used in quality analysis, was realized by means a breakthrough curve in order to validate its total exchange capacity for Mo. The breaking point was determined at (2.75 +/- 0.14) mL, showing that just one 0.5 g Strata X-A cartridge is sufficient to retain 1.0 mL of a (Na₂MoO₄+ ⁹⁹Mo) solution in concentration of 2.42 g L^- 1.

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Author Biography

Marina Fallone Koskinas, Instituto de Pesquisas Energéticas e Nucleares IPEN-CNEN/SP, Nuclear Energy Research Institute

São Paulo SP

References

[1] Phenomenex Strata X-A. https://www.phenomenex.com; access in: [02/18/24].

[2] CHOWDHURY, Z. Z. ;HAMID, S. B. A. and ZAIN, S. M., Evaluating design parameters for breakthrough curve analysis and kinetics of fixed bed columns for Cu(II) cations using lignocellulosic wastes, BioRes. , v.10,n 1, p. 732-749, 2015. Available in : https://bioresources.cnr.ncsu.edu/resources/evaluating-design-parameters-for-breakthrough-curve-analysis-and-kinetics-of-fixed-bed-columns-for-cuii-cations-using-lignocellulosic-wastes/, access in Feb.18th/24. DOI: https://doi.org/10.15376/biores.10.1.732-749

[3] SAID, D.S. Estudo de metodologias de controle de qualidade do Mo-99 utilizado no preparo de geradores MO-99/Tc-99m Dissertação de Mestrado IPEN, 2016.

[4] European directorate for the quality of medicines and healthcare, 2014. Sodium Molybdate (99Mo) Solution (Fission), Ph. Eur., V.8.0, p. 1088-1089, 2014.

[5] SCADDEN, E. M. & BALLOU, N. E. The Radiochemistry of Molybdenum, report, January 1, 1960 ; United States. (https://digital.library.unt.edu/ark:/67531/metadc869270/: accessed March 17, 2025), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

[6] MOHAMMAD, R. F. et al, Targeted elimination of molybdenum ions from a leaching solution with the ability of radiated grafting GMA‑PAN nanofibers, Scientific Reports, 2024.

[7] VOGEL, A. I. Separações por troca iônica. In: Artur Israel VOGEL. Análise química quantitative-Vogel .: LTC – kindle Edition,2022. p. 123-129.ISBN 978-85-216-2579-7.