The image reconstruction influence in relative measurement in SPECT / PET / CT animal

Authors

  • Sarah Soriano , Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission
    • Thiago Barboza Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro
      • Sérgio Augusto Lopes Souza Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro
        • Lidia Vasconcellos de Sá Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission

          DOI:

          https://doi.org/10.15392/bjrs.v6i1.305

          Keywords:

          SPECT/PET/CT animal, reconstruction, preclinical study

          Abstract

          The objective of this study was to evaluate spatial resolution and the influence of different reconstruction methods in a FLEX Triumph ™ Pre-Clinical Imaging System images applied to mice C57BL6 dosimetry in a new radiopharmaceuticals development for humans use. CT and SPECT images were obtained from a homemade phantom containing four spheres with diameters (d) simulating iodine-accumulating injuries at University Hospital (HU / UFRJ). The SPECT images were reconstructed with filtered back projection method (FBP) and the influence in resolution and partial volume effect was evaluated for different filters: Hamming, Hann and Ramp. The resolution found was 9.3 to 9.4 mm, significantly lower than the value provided by the manufacturer, 1.6 mm. Thus, the protocol for mice can be optimized by FBP reconstruction method and Hamming filter, 0.5 cut-off, yielding a resolution from 9.3 to 9.4 mm. This value indicates that iodine-accumulating regions diameter below 9.3 mm is not quantifiable.

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          Author Biographies

          • Sarah Soriano, , Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission
            Pos Graduation student, Medical Physics Department
          • Thiago Barboza, Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro
            Pos Graduation student, Radiology Department
          • Sérgio Augusto Lopes Souza, Clementino Fraga Filho Hospital/Federal University of Rio de Janeiro
            Radiology Department
          • Lidia Vasconcellos de Sá, Institute of Radiation Protection and Dosimetry/National Nuclear Energy Commission
            Medical Physics Department

          References

          MARTIC- KEHL, I. MSCHIBLI, R., SCHUBIGER, A. P. Can animal data predict human outocme? Problems and pitfalls of translational animal research. Eur J Med Mol Imaging,v. 39, p. 1492-1496, 2012.

          MEIKLE R S, KENCH P, KASSIOU M, BANATI BR. Small animal SPECT and its place in the matrix of molecular imaging technologies. Phys Med Biol, v. 50, p. R45-R61, 2005.

          POWSNER R. A, POWSNER E. R. Essential Nuclear Medicine Physics, Blackwell Publisher, Boston & United States of American, 2006.

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          Published

          2018-01-28

          Issue

          Vol. 6 No. 1 (2018)

          Section

          Articles

          License

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